کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2115181 | 1084579 | 2007 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A possible anti-proliferative and anti-metastatic effect of irradiated riboflavin in solid tumours A possible anti-proliferative and anti-metastatic effect of irradiated riboflavin in solid tumours](/preview/png/2115181.png)
Riboflavin is a potent photosensitizer as well as part of the vitamin B complex. Recently we demonstrated that the products generated by irradiation of riboflavin have potential as anti-leukaemic therapy. The possible action, however, of the riboflavin photoproducts in solid cancers has not been addressed. Hence, we investigated the effects of irradiated riboflavin on androgen-independent human prostate cancer cells (PC3), a known model for solid tumour cells with an exceptional resistance to therapy. Our results show that riboflavin photoproducts are cytotoxic to these cells in a FasL–Fas-dependent manner. Furthermore, irradiated riboflavin inhibited matrix-degrading proteases, caused downregulation of VEGF and upregulation of TIMP1 suggesting anti-metastatic potential. Together, these results show that the anti-neoplastic action of riboflavin photoproducts is not limited to haematological malignancies, warranting clinical studies in solid tumours.
Journal: Cancer Letters - Volume 258, Issue 1, 8 December 2007, Pages 126–134