کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2115278 1084584 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Diet-induced obesity and mammary tumor development in relation to estrogen receptor status
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Diet-induced obesity and mammary tumor development in relation to estrogen receptor status
چکیده انگلیسی

Leptin enhances proliferation of estrogen receptor (ER)-positive breast cancer cells in vitro. Here, we compared mammary tumor (MT) formation from ER-positive (MCF-7) and ER-negative (MDA-MB-231) breast cancer cells in athymic mice fed a High-Fat diet to elevate serum leptin. Neither body weight, diet or serum leptin levels impacted MT latency, burden or tumor grade. However, protein expression in mammary fat pads exhibited elevated PCNA and Cyclin D1 while in MTs, Ob-Rb, IGF-IR, Bcl-2, and Bax were lower in Low-Fat versus High-Fat mice. In conclusion, diet rather than serum leptin impacted breast cancer cell tumor metabolism.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 253, Issue 2, 18 August 2007, Pages 291–300
نویسندگان
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