کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2115501 1084597 2006 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Influence of galangin on HL-60 cell proliferation and survival
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Influence of galangin on HL-60 cell proliferation and survival
چکیده انگلیسی

The effect of galangin, a flavonol component of India root spice and the ‘herbal’ medicine propolis, on HL-60 human leukaemia cell survival is characterised. Galangin (1–100 μM) exerted an antiproliferative effect that, with dose and exposure longevity, was progressively associated with an elevated hypodiploid DNA content and expression of the active form of caspase-3, principally prior to membrane damage. At ≥50 μM, plasmamembrane phosphatidylserine exposure was observed. There was no evidence for intracellular oxidative stress as an orchestrator of cytotoxicity and significant phagocyte-like differentiation was not detected. We discuss whether such cytotoxicity will be therapeutically exploitable or contribute to cancer prevention within a pharmacological or dietary context.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 243, Issue 1, 8 November 2006, Pages 80–89
نویسندگان
, ,