کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2116321 | 1084835 | 2013 | 10 صفحه PDF | دانلود رایگان |

Glioblastoma is the most common and fatal type of primary brain tumors featured with hyperplastic blood vessels. Here, we performed meta-analyses of published data and established a correlation between high TIP-1 expression levels and the poor prognosis of glioblastoma patients. Next, we explored the biological relevance of TIP-1 expression in the pathogenesis of glioblastoma. By using orthotopic and heterotopic mouse models of human glioblastomas, this study has characterized TIP-1 as one contributing factor to the tumor-driven angiogenesis. In vitro and in vivo functional assays, along with biochemical analyses with microarrays and antibody arrays, have demonstrated that TIP-1 utilizes multiple pathways including modulating fibronectin gene expression and uPA protein secretion, to establish or maintain a pro-angiogenic microenvironment within human glioblastoma. In conclusion, this work supports one hypothesis that TIP-1 represents a novel prognostic biomarker and a therapeutic target of human glioblastoma.
► The elevated TIP-1 expression levels correlate with the advanced staging and poor prognosis of human malignant gliomas.
► TIP-1 primarily promotes tumor-driven angiogenesis in glioblastoma.
► Both of gene expression and protein secretion might contribute to the TIP-1 regulated angiogenesis.
► TIP-1 represents one novel prognostic biomarker and therapeutic target of human glioblastoma.
Journal: Cancer Letters - Volume 328, Issue 1, 1 January 2013, Pages 55–64