کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2116878 | 1085040 | 2007 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lytic induction and apoptosis of EpsteinâBarr virus-associated gastric cancer cell line with epigenetic modifiers and ganciclovir
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Lytic induction and apoptosis of EpsteinâBarr virus-associated gastric cancer cell line with epigenetic modifiers and ganciclovir Lytic induction and apoptosis of EpsteinâBarr virus-associated gastric cancer cell line with epigenetic modifiers and ganciclovir](/preview/png/2116878.png)
چکیده انگلیسی
EpsteinâBarr virus (EBV) is an oncogenic herpes virus. EBV gene transcription is regulated by an epigenetic mechanism to establish a persistent infection and to evade the host immune system. We found that low concentrations of epigenetic modifying agents, 5-aza-2â²-deoxycytidine (5-aza-CdR) or trichostatin A (TSA), induced the expression of BMRF1, BZLF1, and BRLF1 genes, which are found in the lytic form of the virus, in an EBV-positive gastric cancer cell line. This effect did not involve PI3 kinase, MAP/ERK kinase, protein kinase C δ, or p38 MAPK signaling pathway. The cytotoxic effect of ganciclovir (GCV) was enhanced after the lytic induction by epigenetic modifiers, and the combination of GCV and epigenetic modifiers induced apoptosis, which is dependent on caspases. In conclusion, the combination of GCV with 5-aza-CdR or TSA might be a useful therapeutic strategy for EBV-induced human gastric cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 247, Issue 1, 8 March 2007, Pages 77-83
Journal: Cancer Letters - Volume 247, Issue 1, 8 March 2007, Pages 77-83
نویسندگان
Eun Ji Jung, You Mie Lee, Byung Lan Lee, Mee Soo Chang, Woo Ho Kim,