کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2120581 1546860 2007 21 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Drugs and drug resistance in African trypanosomiasis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Drugs and drug resistance in African trypanosomiasis
چکیده انگلیسی

Despite the many decades of use of most of the current trypanocides, we know little of their mode of action. This may in part be because most of these will act on multiple targets once inside the cell, and they derive their selective action on the parasite from selective accumulation by the pathogen. Loss of this capacity for drug uptake by the trypanosome would thus be a major cause for drug resistance. We here discuss the use of current drugs against human and veterinary African trypanosomiasis, the prevalence, causes and mechanisms of drug resistance and new developments in trypanosomiasis therapy such as the introduction of nifurtimox and DB289.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug Resistance Updates - Volume 10, Issues 1–2, February–April 2007, Pages 30–50
نویسندگان
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