کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2121922 1547120 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Primary brain tumours, meningiomas and brain metastases in pregnancy: Report on 27 cases and review of literature
ترجمه فارسی عنوان
تومورهای مغزی اولیه، مننژیم ها و متاستازهای مغزی در حاملگی: گزارش 27 مورد و بررسی ادبیات
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی

BackgroundThe concurrence of intracranial tumours with pregnancy is rare. The purpose of this study was to describe all reported patients registered in the international Cancer in Pregnancy registration study (CIP study; http://www.cancerinpregnancy.org), and to review the literature in order to obtain better insight into outcome and possibilities of treatment in pregnancy.MethodsWe collected all intracranial tumours (primary brain tumour, cerebral metastasis, or meningioma) diagnosed during pregnancy, registered prospectively and retrospectively by international collaboration since 1973. Patients diagnosed postpartum were excluded. We summarised the demographic features, treatment decisions, obstetrical and neonatal outcomes.ResultsThe mean age of the 27 eligible patients was 31 years (range 23–41 years), of which 13 and 12 patients were diagnosed in the second and third trimesters, respectively. Eight patients (30%) underwent brain surgery, seven patients (26%) had radiotherapy and in three patients (11%) chemotherapy was administered during gestation. Two patients died during pregnancy and four pregnancies were terminated. In 16 (59%) patients elective caesarean section was performed of which 14 (52%) were still preterm (range 30–36 weeks, mean 33 weeks). Five patients had a vaginal delivery (range 36–40 weeks). Of the 21 ongoing pregnancies all children were born alive without visible congenital malformations and the available long-term follow-up data (range 2–25 years) of six children were reassuring.ConclusionAdherence to standard protocol for the treatment of brain tumours during pregnancy appears to allow a term delivery and a higher probability of a vaginal delivery.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cancer - Volume 50, Issue 8, May 2014, Pages 1462–1471
نویسندگان
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