کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2125229 | 1547216 | 2010 | 9 صفحه PDF | دانلود رایگان |
Aim of the studyTo examine risk factors for developing hypertension in childhood cancer survivors (CCS).MethodsWe conducted a nested case-control study of risk for hypertension within a cohort of 1362 childhood cancer survivors treated between 1966 and 1996 in the Emma’s Children’s Hospital/Academic Medical Center in the Netherlands. Detailed information on treatment and several lifestyle factors was collected for 44 cases with hypertension and 123 matched controls. Odds ratios (ORs) for hypertension were calculated by conditional logistic regression analysis.ResultsBody Mass Index (BMI) was the only significant risk factor associated with the occurrence of hypertension (OR 3.95; 95% confidence interval (CI) 1.7–9.1 for BMI ⩾ 25 kg/m2 compared to BMI < 25 kg/m2). However, cisplatin, cyclophosphamide and radiotherapy (RT) to the abdominal region were all associated with non-significant risk increases (ORs of 4.3, 2.1, and 1.8, respectively).ConclusionOur results show that BMI is the most important risk factor for hypertension following treatment of childhood cancer, emphasising the need for CCS to maintain a normal weight.
Journal: European Journal of Cancer - Volume 46, Issue 4, March 2010, Pages 782–790