کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2136968 | 1087827 | 2013 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Intracellular superoxide dismutase activity defines invasiveness of the murine T-lymphoma cell line L5187Y-ML25 in vitro and in vivo
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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چکیده انگلیسی
Superoxide anion in the tumor microenvironment promotes a malignant phenotype. Here, we examined superoxide in a murine T-lymphoma cell line L5187Y-ML25. Clones with high and low intracellular superoxide dismutase (SOD) activities were obtained from parental L5187Y-ML25 cells and were subjected to assays determining cell invasiveness, motility, and in vivo dissemination. Cells with lower SOD activity exhibited higher invasiveness in vitro and in vivo. NADPH oxidase inhibitor suppressed intracellular free radical levels and cell motility, suggesting NADPH oxidase as a source of superoxides that stimulates cell motility. These results implicate superoxide as a potential anti-metastatic therapy for hematopoietic cell malignancies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 37, Issue 1, January 2013, Pages 89–92
Journal: Leukemia Research - Volume 37, Issue 1, January 2013, Pages 89–92
نویسندگان
Maki Tanaka, Kageaki Kuribayashi, Kastuhisa Kogawa, Kiminori Nakamura, Naoki Watanabe,