کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2140795 | 1088261 | 2015 | 5 صفحه PDF | دانلود رایگان |
• EGFR-mutated lung adenocarcinoma belongs to the spectrum of predisposed neoplasms in LFS.
• We provide the first description of resistance mutation to EGFR-TKI in a patient with LFS and lung adenocarcinoma.
• Response to targeted therapy may benefit to the same extent to LFS patient as in the general population.
We report two cases of non-smoker patients diagnosed with EGFR-mutated lung adenocarcinoma and bearing germinal TP53 gene mutation, also known as Li-Fraumeni syndrome (LFS). We describe for the first time an EGFR-TKI resistance mutation in this population. Finally, we provide an analysis of discerning epidemiological data obtained from the IARC database and from all the published cases of EGFR-mutated lung cancer in TP53 germline mutation carriers.
Journal: Lung Cancer - Volume 87, Issue 1, January 2015, Pages 80–84