کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2148434 | 1089562 | 2010 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Programmed cell death triggered by nucleotide pool damage and its prevention by MutT homolog-1 (MTH1) with oxidized purine nucleoside triphosphatase
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کلمات کلیدی
PARP2-OH-dATPMTH18-oxo-dGTPOGG18-oxoGBER2-hydroxyadenine - 2-هیدروکسی آپیدین8-oxoguanine - 8-اکسوگوینینROS - ROSSSBs - SSBAIF - آیفونNucleotide pool - استخر نوکلئوتیدbase excision repair - تعمیر پایه پایهSOD - سدSuperoxide dismutase - سوکسوکس دیسموتازsingle strand breaks - شکاف تک رشته ایapoptosis-inducing factor - عامل القاء آپوپتوزProgrammed cell death - مرگ برنامهریزی شده یاختهMUTYH - موتیفNitric oxide - نیتریک اکسیدPoly(ADP-ribose) polymerase - پلیمر (ADP-ribose) پلیمرازReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Programmed cell death triggered by nucleotide pool damage and its prevention by MutT homolog-1 (MTH1) with oxidized purine nucleoside triphosphatase Programmed cell death triggered by nucleotide pool damage and its prevention by MutT homolog-1 (MTH1) with oxidized purine nucleoside triphosphatase](/preview/png/2148434.png)
چکیده انگلیسی
Accumulation of oxidized bases such as 8-oxoguanine in either nuclear or mitochondrial DNA triggers various cellular dysfunctions including mutagenesis, and programmed cell death or senescence. Recent studies have revealed that oxidized nucleoside triphosphates such as 8-oxo-dGTP in the nucleotide pool are the main source of oxidized bases accumulating in the DNA of cells under oxidative stress. To counteract such deleterious effects of nucleotide pool damage, mammalian cells possess MutT homolog-1 (MTH1) with oxidized purine nucleoside triphosphatase and related enzymes, thus minimizing the accumulation of oxidized bases in cellular DNA. Depletion or increased expression of the MTH1 protein have revealed its significant roles in avoiding programmed cell death or senescence as well as mutagenesis, and accumulating evidences indicate that MTH1 is involved in suppression of degenerative disorders such as neurodegeneration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mutation Research/Genetic Toxicology and Environmental Mutagenesis - Volume 703, Issue 1, 28 November 2010, Pages 51-58
Journal: Mutation Research/Genetic Toxicology and Environmental Mutagenesis - Volume 703, Issue 1, 28 November 2010, Pages 51-58
نویسندگان
Yusaku Nakabeppu, Sugako Oka, Zijing Sheng, Daisuke Tsuchimoto, Kunihiko Sakumi,