Keywords: Hx; hypoxanthine; 8-oxoG; 8-oxoguanine; DNA damage; Cancer; Hypoxanthine; Inosine; Inflammation; MPG; Mutation; OGG1; Reactive oxygen and nitrogen species; Base excision repair; Site-specific mutagenesis; Deamination damage;
مقالات ISI (ترجمه نشده)
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Keywords: AgNPs; silver nanoparticles; cit; citrate; PVP; polyvinylpyrrolidone; AgOAc; silver acetate; Ag+;  silver ions; 8-oxoG; 7,8-dihydro-8-oxoguanine; γ-H2AX; phosphorylated histone 2AX; DSBs; double strand breaks; MN; micronuclei; SPR; surface plasmon reson
Keywords: BER; base excision repair; EV; electronic volume; GSH; glutathione; HPRT; hypoxanthine-guanine phosphoribosyl transferase; MMR; mismatch repair; MSI; microsatellite instability; NAC; N-acetylcysteine; NSAID; nonsteroidal anti-inflammatory drug; 8-oxoG;
Keywords: 8-oxoG; 7,8-dihydro-8-oxoguanine; AECs; airway epithelial cells; AHR; airway hyperresponsiveness; APE1; AP-endonuclease 1; AP sites; apurinic/apyrimidinic site; BER; base excision repair; BALF; bronchoalveolar lavage fluid; CA; comet assay; DSB; double-st
General misincorporation frequency: Re-evaluation of the fidelity of DNA polymerases
Keywords: Misincorporation frequency; DNA polymerase; Nucleotide incorporation; dNTP; deoxynucleoside triphosphate; rNTP; ribonucleoside triphosphate; rNMP; ribonucleoside monophosphate; PaP; Pseudomonas aeruginosa phage; Pol; polymerase; Gp90 exoâ; exonuclease-d
Neurotoxicity of cytarabine (Ara-C) in dorsal root ganglion neurons originates from impediment of mtDNA synthesis and compromise of mitochondrial function
Keywords: DRG; dorsal root ganglion; mtDNA; mitochondrial DNA; BER; base excision repair; NER; nucleotide excision repair; DDR; DNA damage response; OCR; oxygen consumption rate; PNS; peripheral nervous system; pol γ; DNA polymerase γ; ROS; reactive oxygen specie
Effects of the stimuli-dependent enrichment of 8-oxoguanine DNA glycosylase1 on chromatinized DNA
Keywords: 8-oxoG; 8-oxo-7, 8-dihydroguanine; AP; apurinic/apyrimidinic site in DNA; APE1; apurinic/apyrimidinic endonuclease 1; BER; base excision repair; ChIP; chromatin immunoprecipitation assays; ChIP-seq; chromatin immunoprecipitation assays followed by DNA seq
The roles of human MTH1, MTH2 and MTH3 proteins in maintaining genome stability under oxidative stress
Keywords: 6-TG; 6-thioguanine; 8-oxoG; 8-oxo-7,8-dihydroguanine; MTH1; MutT Homolog 1; Reactive oxygen species; ROS; 8-oxoguanine (8-oxoG); Genomic instability; MutT homolog; Nucleoside/nucleotide metabolism; Nudix; Oxidative stress;
8-Oxoguanine DNA glycosylase 1: Beyond repair of the oxidatively modified base lesions
Keywords: ROS; reactive oxygen species; 8-oxoG; 7, 8-dihydro-8-oxoguanine; OGG1; 8-oxoguanine DNA glycosylase 1; BER; base excision repair; OGG1-BER; OGG1-initiated DNA base excision repair; IIR; innate immune response; TNFα; Tumor necrosis factor alpha; NF-κB; N
Simplified qPCR method for detecting excessive mtDNA damage induced by exogenous factors
Keywords: mtDNA; mitochondrial DNA; 8-oxoG; 8-oxo-7,8-dihydro-2â²-deoxyguanosine; FPG; formamidopyrimidine DNA glycosylase; HSP; H-strand promoter; OR; origin of replication; TAS; termination-associated sequence; Mitochondrial DNA; Oxidative damage; Hydrogen perox
Removal of oxidatively generated DNA damage by overlapping repair pathways
Keywords: BER; base excision repair; NER; nucleotide excision repair; NIR; nucleotide incision repair; ROS; reactive oxygen species; RNS; reactive nitrogen species; GG; global genomic; TC; transcription coupled; cdG; 5â²,8-cyclo-2â²-deoxyguanosine; cdA; 5â²,8-cy
Human NEIL1 DNA glycosylase: Structure, function and polymorphisms
Keywords: 8-oxoG; 8-dihydro-2â²-deoxyguanosine; 5-OHU; 5-hydroxyuracil; AP; apurinic/apyrimidinic; BER; base excision repair; CCA; cholangiocarcinoma; DHU; 5,6 dihydrouracil; DSB; double-strand breaks; dRP; deoxyribose phosphate; Fapy-A; 4,6-diamino-5-formamidopyr
DNA repair and systemic lupus erythematosus
Keywords: 8-oxoG; 8-hydroxyguanosine; OGG1; 8-oxoguanine DNA glycosylase; ARTD1; ADP-ribosyltransferase diphtheria toxin-like 1; ATM; Ataxia telangiectasia mutated; BER; base excision repair; BMDMs; bone marrow-derived macrophages; CSR; lass switch recombination; C
Radiation-induced clustered DNA lesions: Repair and mutagenesis
Keywords: LET; linear energy transfer; MDS; multiply damaged site; SSB; single strand break; DSB; double strand break; AP sites; abasic sites; 8-oxoG; 8-oxo-7,8-dihydroguanine; 5-ohU; 5-hydroxyuracil; Tg; 5,6-dihydroxy-5,6-dihydrothymine; U; uracil; BER; base excis
Chromatin associated mechanisms in base excision repair - nucleosome remodeling and DNA transcription, two key players
Keywords: DNA oxidative damage; Base excision repair; OGG1; 8-oxoG; Transcription coupled repair; Nucleosome; Chromatin; Chromatin remodeling;
Aberrant base excision repair pathway of oxidatively damaged DNA: Implications for degenerative diseases
Keywords: ROS; reactive oxygen species; AP; apurinic/apyrimidinic site; 8-oxoG; 8-oxo-7,8-dihydroguanine; 8-oxoA; 8-oxo-7,8-dihydroadenine; Fapy; formamidopyrimidines; 2-oxoA; 2-hydroxyadenine; Thymine glycol; 5,6-dihydroxy-5,6-dihydrothymine; Hx; hypoxanthine; εA
Repair of 8-oxoG:A mismatches by the MUTYH glycosylase: Mechanism, metals and medicine
Keywords: G; guanine; C; cytosine; A; adenine; T; thymine; MMR; mismatch repair; BER; base excision repair; UDG; uracil DNA glycosylase; 8-oxoG; 8-oxo-7,8-dihydroguanine; CRC; colorectal cancer; MUTYH; MutY homolog; MAP; MUTYH-associated polyposis; RONS; reactive o
8-Oxoguanine DNA glycosylase1-driven DNA repair-A paradoxical role in lung aging
Keywords: 8-oxoG; 7,8-dihydro-8-oxoguanine; 8-oxodG; 7,8-dihydro-8-oxo-2â²-deoxyguanosine; BER; base excision repair; DNA dsbs; double strand breaks; DNA ssbs; single strand breaks; GEF; guanine nucleotide exchange factor; GOrilla; Gene Ontology enrichment analysi
Not breathing is not an option: How to deal with oxidative DNA damage
Keywords: OGG1; MUTYH; DNA polymerase β; DNA polymerase λ; DNA polymerase δ; 8-oxo-G; 8-oxoG; DNA polymerase switch; Oxidative stress; Cancer;
Kinetic analysis of bypass of 7,8-dihydro-8-oxo-2′-deoxyguanosine by the catalytic core of yeast DNA polymerase η
Keywords: 8-oxoG; Yeast DNA polymerase ηcore; dNTP incorporation; Pre-steady-state enzyme kinetics
Potential role of 8-oxoguanine DNA glycosylase 1 as a STAT1 coactivator in endotoxin-induced inflammatory response
Keywords: BER; base excision repair; ChIP; chromatin immunoprecipitation; COX-2; cyclooxygenase-2; EAE; experimental autoimmune encephalomyelitis; faPyG; 2,6-diamino-4-hydroxy-5-formamidopyrimidine; GAS; gamma-interferon activation site; iNOS; inducible nitric oxid
House dust mite-induced asthma causes oxidative damage and DNA double-strand breaks in the lungs
Keywords: House dust mite; asthma; oxidative stress; DNA double-strand breaks; BEAS-2B; cell death; DNA repair; NU7441; AHR; Airway hyperresponsiveness; ATM; Ataxia-telangiectasia mutated; BAL; Bronchoalveolar lavage; CC10; Club cell 10Â kDa protein; DCFH-DA; 2,7-D
OGG1 is essential in oxidative stress induced DNA demethylation
Keywords: OGG1; 8-Oxoguanine DNA glycosylase-1; 8-oxoG; 8-Oxoguanine; ROS; reactive oxygen species; α-KG; α-Ketoglutarate; MeDIP; methylated DNA immunoprecipitations; 5mC; 5-Methyl cytosine; 5hmC; 5-Hydroxymethyl cytosine; 5fC; 5-Formylcytosine; 5caC; 5-Carboxylc
Association between single nucleotide polymorphisms of MUTYH, hOGG1 and NEIL1 genes, and depression
Keywords: RDD; recurrent depression disorder; IL-1β; interleukin-1b; IL-8; interleukin-8; NLR; Nod-like receptor; PBMCs; peripheral blood mononuclear cells; mtROS; mitochondrial reactive oxygen species; 8-oxoG; 8-oxoguanine; SNPs; single nucleotide polymorphisms;
Knockout of the ergothioneine transporter ETT in zebrafish results in increased 8-oxoguanine levels
Keywords: 8OG, 8-oxoguanine (8-oxo-7,8-dihydroguanine); CTT, carnitine transporter; ET, ergothioneine; ETT, ergothioneine transporter; HNE, 4-hydroxynonenal; LC, liquid chromatography; MDA, malondialdehyde; MS, mass spectrometryErgothioneine; Singlet oxygen; 8-Oxog
Efficient cleavage of single and clustered AP site lesions within mono-nucleosome templates by CHO-K1 nuclear extract contrasts with retardation of incision by purified APE1
Keywords: Clustered DNA damage; BER; Nucleosome; AP site; 8-oxoG;
Whole transcriptome analysis reveals a role for OGG1-initiated DNA repair signaling in airway remodeling
Keywords: 8-oxoG; 7,8-dihydro-8-oxoguanine; BER; base-excision repair; CASAVA; consensus assessment of sequence and variation; COPD; chronic obstructive pulmonary disease; ECM; extracellular matrix; GENE-E; a matrix visualization and analysis platform; GEO; Gene Ex
Viral infection-oxidative stress/DNA damage-aberrant DNA methylation: separate or interrelated events responsible for genetic instability and childhood ALL development?
Keywords: AID; activation-induced cytidine deaminase; ALL; acute lymphoblastic leukemia; APOBEC; apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like deaminase BER, base excision repair; 5-hmCyt; 5-hydroxymethylcytosine; 5-hmUra; 5-hydroxymethyluracil; 5
8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and α-smooth muscle actin polymerization
Keywords: ROS; OGG1; Base excision repair; Rho-GTP; Cytoskeleton; Free radicals; 8-oxoG; 8-oxo-7,8-dihydroguanine; 8-oxodG; 8-oxo-7,8-dihydro-2â²-deoxyguanosine; α-SMA; α-smooth muscle actin; Ab; antibody; BER; base excision repair; FU; fluorescence unit; Fapy
Tracing the fates of site-specifically introduced DNA adducts in the human genome
Keywords: TATAM; tracing DNA adducts in targeted mutagenesis; 8-oxoG; 8-oxo-7,8-dihydroguanine; TK; thymidine kinase gene; HR; homologous recombination; DSB; double-strand break; MYH; human MutY homolog; DNA adducts; Mutagenesis; Gene targeting; 8-Oxoguanine (8-oxo
Lipid peroxidation product 4-hydroxy-2-nonenal modulates base excision repair in human cells
Keywords: 4-Hydroxy-2-nonenal; HNE-DNA adducts; Base excision repair; Ligation, OGG1, TDG, ANPG, APE1; Acr; acrolein; ANPG; alkyl-N-purine glycosylase; AP-site; apurinic/apyrimidinic site; APE1; AP-site endonuclease; BER; base excision repair; BSA; bovine serum a
Oxidative modification enhances the immunostimulatory effects of extracellular mitochondrial DNA on plasmacytoid dendritic cells
Keywords: 7-AAD; 7-aminoactinomycin-D; 8-oxoG; 8-oxo-7,8-dihydroguanine; 8-oxodG; 8-oxo-7,8-dihydro-2â²'-deoxyguanosine; DAMP; damage-associated molecular pattern; IFN; interferon; pDCs; plasmacytoid dendritic cells; mtDNA; mitochondrial DNA; ODN; oligodeoxynucl
Combined analysis of polymorphism variants in hMTH1, hOGG1 and MUTYH genes on the risk of type 2 diabetes in the Chinese population
Keywords: 8-oxoG; 7,8-dihydro-8-oxoguanine; BER; base excision repair; hMTH1; human mutT homolog 1; MUTYH; human mutY homolog; hOGG1; human 8-oxoguanine glycosylase 1; HRM; high-resolution melting; ROS; reactive oxygen species; SNPs; single nucleotide polymorphisms
Alzheimer's disease-associated polymorphisms in human OGG1 alter catalytic activity and sensitize cells to DNA damage
Keywords: AD; Alzheimer's disease; 8-oxoG; 7,8-dihydro-8-oxoguanine; OGG1; 8-oxoguanine-DNA glycosylase; PARP-1; poly(ADP-ribose) polymerase 1; XRCC1; X-ray cross-complementing protein 1; ROS; reactive oxygen species; BER; base excision repair; MEF; mouse embryo fi
8-Oxoguanine DNA glycosylase-1 links DNA repair to cellular signaling via the activation of the small GTPase Rac1
Keywords: 8-oxoG; 8-oxo-7,8-dihydroguanine; 8-oxodG; 8-oxo-7,8-dihydro-2â²-deoxyguanosine; 8-OH-Ade; 8-oxo-7,8-dihydroadenine; APE1; apurinic/apyrimidinic endonuclease 1; DNA BER; base excision repair; FapyG; 2,6-diamino-4-hydroxy-5-formamidopyrimidine; FU; fluore
Age-dependent guanine oxidation in DNA of different brain regions of Wistar rats and prematurely aging OXYS rats
Keywords: Abs; antibodies; DAPI; 4â²,6-diamidino-2-phenylindole; GFAP; glial fibrillary acidic protein; OGG1; 8-oxoguanine DNA glycosylase; 8-oxoG; 8-oxoguanine; PBS; phosphate-buffered saline; Premature aging; OXYS rats; Brain; Guanine oxidation; Immunofluorescen
Oxidative stress, DNA damage, and the telomeric complex as therapeutic targets in acute neurodegeneration
Keywords: MDA; malondialdehyde; 4-HNE; 4-hydroxynonenal; EAE; experimental allergic encephalomyelitis; MS; mutiple sclerosis; SSB; single strand break; DSB; double strand break; 8-OxoG; 8-hydroxyguanosine; 8-NO(2)-G; 8-nitroguanine; AP; apurinic/apyrmidinic; OGG1;
Thymidine glycol: the effect on DNA molecular structure and enzymatic processing
Keywords: Oxidative DNA damage; Thymine glycol repair; Translesion synthesis; Alteration in DNA structure; Tandem (clustered) lesions; Tg; thymine glycol; Tg*; thymidine glycol; Ug; uracil glycol; dUg; 2â²-deoxyuridine glycol; 8-oxoG; 8-oxo-7,8-dihydro-2â²-deoxyg
C-terminal region of HBx is crucial for mitochondrial DNA damage
Keywords: HBx; mtDNA damage; 8-Oxoguanine; 8-oxoG; C-terminal truncated HBx8-oxoG, 8-Oxoguanine; HBV, Hepatitis B virus; HBx, Hepatitis B virus X protein; HCC, Hepatocellular carcinoma; mtCYTB, Mitochondrial cytochrome B; mtDNA, Mitochondrial DNA; nDNA, Nuclear DNA
Aerobic endurance capacity affects spatial memory and SIRT1 is a potent modulator of 8-oxoguanine repair
Keywords: 8-oxoG; 8-oxo-7,8-dihydroguanine; Ac; acetylated; AcOgg1; acetylated 8-oxoguanine DNA glycosylase-1; AP; abasic; APE1; apurinic apyrimidinic endonuclease1; BER; base excision repair; BrdU; 5-bromo-2â²-deoxyuridine; DNPH; 4-dinitrophenylhydrazine; ERK; ex
Regulation of DNA repair by S-nitrosylation
Keywords: 8-oxoG; 8-oxoguanine; AGT; O6-alkylguanine-DNA-alkyltransferase; AP; apurinic-apyrimidinic; APE1; AP endonuclease 1; BER; base excision repair; DEN; diethylnitrosamine; DNA-PKcs; DNA-dependent protein kinase catalytic subunit; DSB; double-strand break; DT
Sporadic Alzheimer disease fibroblasts display an oxidative stress phenotype
Keywords: Alzheimer disease; Oxidative stress; Array analysis; 8-OxoG; Oxidative DNA damage; Free radicals
Accumulation of nuclear and mitochondrial DNA damage in the frontal cortex cells of patients with HIV-associated neurocognitive disorders
Keywords: HAND; AIDS; ROS; HIV-1; Mitochondria; mtDNA; 8-oxoG
Age-dependent changes in 8-oxoguanine-DNA glycosylase activity are modulated by adaptive responses to physical exercise in human skeletal muscle
Keywords: Exercise; Aging; DNA damage/repair; Sirtuins; Antioxidants; 8-OxoG; OGG1; Acetylation; Free radicals;
Methanol exposure does not produce oxidatively damaged DNA in lung, liver or kidney of adult mice, rabbits or primates
Keywords: MeOH; methanol; ROS; reactive oxygen species; 8-oxodG; 8-oxo-2â²-deoxyguanosine; 8-oxoG; 8-oxoguanine; OGG1; oxoguanine glycosylase 1; KBRO3; potassium bromate; KO; knockout; POBN; alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone; NEDO; New Energy Developme
Delayed repair of radiation induced clustered DNA damage: Friend or foe?
Keywords: AP; abasic; DSB; double strand breaks; SSB; single strand breaks; LET; linear energy transfer; BER; base excision repair; 8-oxoG; 8-oxo-7,8-dihydroguanine; Tg; thymine glycol; DHT; 5,6-dihydrothymine; hU; 5-hydroxyuracil; 8-oxoA; 8-oxo-7,8-dihydroadenine;
Induction of the intrinsic apoptosis pathway in insulin-secreting cells is dependent on oxidative damage of mitochondria but independent of caspase-12 activation
Keywords: 8-oxoG; 8-oxoguanine; CHOP; CAAT/enhancer binding protein homologous transcription factor; H2O2; hydrogen peroxide; IAP; inhibitor of apoptosis protein; IFN-γ; interferon-γ; IL-1β; interleukin-1β; iNOS; inducible nitric oxide synthase; JNK; c-Jun N-te
Nectarine promotes longevity in Drosophila melanogaster
Keywords: DR; dietary restriction; sod1; superoxide dismutase 1; TOR; target of rapamycin; JNK; Jun kinase; 8-oxoG; 8-oxoguanine; SY; sugar-yeast extract; RNAi; RNA interference; UAS-sod1IR; UAS-sod1 inverted repeat; da-Gal4; daughterless-Gal4; DAMS; Drosophila A
Incidence and persistence of 8-oxo-7,8-dihydroguanine within a hairpin intermediate exacerbates a toxic oxidation cycle associated with trinucleotide repeat expansion
Keywords: 8-oxoG; 8-oxo-7,8-dihydroguanine; AP; apurinic; APE1; apurinic endonuclease 1; BER; base excision repair; BSA; bovine serum albumin; DMT; dimethoxytrityl; EDTA; ethylenediaminetetraacetic acid; FEN1; flap endonuclease 1; HD; Huntington's disease; hOGG1; h
Clustered DNA lesion repair in eukaryotes: Relevance to mutagenesis and cell survival
Keywords: DSB; double strand break; MDS; multiply damaged sites; SSB; single strand break; LET; linear energy transfer; BER; base excision repair; NER; nucleotide excision repair; HR; homologous recombination; NHEJ; non-homologous end-joining; PRR; post-replication