کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10738684 | 1046721 | 2011 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nectarine promotes longevity in Drosophila melanogaster
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کلمات کلیدی
JnkSOD1PRXPEPCK8-oxoGTOR4-hydroxynonenal4-HNEqPCR8-oxoguanine - 8-اکسوگوینینRNA interference - RNA تداخل کنندهRNAi - RNA سرکوبگر،RNA مداخلهگر، RNA خاموش کنندهNutraceutical - بیضه ایOxidative stress - تنش اکسیداتیوFree radicals - رادیکال آزادAging - سالخوردگیDams - سدهاsuperoxide dismutase 1 - سوپر اکسید دیسموتاز 1Nectarine - شلیلLife span - طول عمرphosphoenolpyruvate carboxykinase - فسفوآنولپیرود کربوکسیکینازdietary restriction - محدودیت غذاییJNK signaling pathway - مسیر سیگنال JNKtarget of rapamycin - هدف از رپامایسینPeach - هلوquantitative polymerase chain reaction - واکنش زنجیره ای پلیمراز کمیPeroxiredoxin - پروکسی ردوکسینreproductive aging - پیری تولید مثلJun kinase - ژوئن کیناز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Fruits containing high antioxidant capacities and other bioactivities are ideal for promoting longevity and health span. However, few fruits are known to improve the survival and health span in animals, let alone the underlying mechanisms. Here we investigate the effects of nectarine, a globally consumed fruit, on life span and health span in Drosophila melanogaster. Wild-type flies were fed standard, dietary restriction (DR), or high-fat diet supplemented with 0-4% nectarine extract. We measured life span, food intake, locomotor activity, fecundity, gene expression changes, and oxidative damage indicated by the level of 4-hydroxynonenal-protein adduct in these flies. We also measured life span, locomotor activity, and oxidative damage in sod1 mutant flies on the standard diet supplemented with 0-4% nectarine. Supplementation with 4% nectarine extended life span, increased fecundity, and decreased expression of some metabolic genes, including a key gluconeogenesis gene, PEPCK, and oxidative stress-response genes, including peroxiredoxins, in female wild-type flies fed the standard, DR, or high-fat diet. Nectarine reduced oxidative damage in wild-type females fed the high-fat diet. Moreover, nectarine improved the survival of and reduced oxidative damage in female sod1 mutant flies. Together, these findings suggest that nectarine promotes longevity and health span partly by modulating glucose metabolism and reducing oxidative damage.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 50, Issue 11, 1 June 2011, Pages 1669-1678
Journal: Free Radical Biology and Medicine - Volume 50, Issue 11, 1 June 2011, Pages 1669-1678
نویسندگان
Olga Boyd, Peter Weng, Xiaoping Sun, Thomas Alberico, Mara Laslo, David M. Obenland, Bradley Kern, Sige Zou,