Age-dependent guanine oxidation in DNA of different brain regions of Wistar rats and prematurely aging OXYS rats

► An inbred prematurely aging OXYS and control Wistar rats were used. ► OXYS is characterized by high sensitivity to oxidative stress, learning and memory deterioration. ► We have analyzed base lesion 8-oxoguanine in different brain regions of these rats. ► 8-OxoG increased in neurons, nestin- and (GFAP)-positive cells of hippocampus and frontal cortex. ► OXYS rats demonstrate significantly higher levels of oxidative brain DNA damage than Wistar rats.