کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2148859 | 1548634 | 2008 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Copper, zinc-superoxide dismutase enhances the mutagenicity in Salmonella typhimurium induced by 2-amino-6-methyldipyrido[1,2-a:3â²,2â²-d]imidazole
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کلمات کلیدی
Trp-P-2DMNCDNBG6PG6PDHGlu-P-1XODMeIQxCuZn-SODPhIPTrp-P-12-aminoanthraceneo-AminoazotolueneGlu-P-2DAF2-aminodipyrido[1,2-a:3′,2′-d]imidazoleGSTGSHCyPMeAαCPCBN,N-dimethylnitrosamineN-hydroxylationXanthine oxidase - زانتین اکسیداز1-chloro-2,4-dinitrobenzene - 1-کلرو-2،4-دینیتروبنزن2-amino-3-methyl-9H-pyrido[2,3-b]indole - 2-amino-3-methyl-9H-pyrido [2،3-b] indole2-amino-3-methylimidazo[4,5-f]quinoline - 2-amino-3-methylimidazo [4،5-f] quinoline2-aminofluorene - 2-آمینوفلوئورنAFB1 - AFB 1O2− - O2-Aflatoxin B1 - آفلاتوکسین B1Heterocyclic amine - آمین heterocyclicInternational Agency for Research on Cancer - آژانس بین المللی تحقیقات سرطانIARC یا International Agency for Research on Cancer - آژانس بین المللی تحقیقات سرطانBenzo[a]pyrene - بنزو [a] پییرنMutagenicity - جهش زاییOat - جو دو سرSuperoxide anion radical - رادیکال آنیون سوپراکسیدSalmonella Typhimurium - سالمونلا تیفی موریومCytosol - سیتوزولCytochrome P450 - سیتوکروم پی۴۵۰copper, zinc-superoxide dismutase - مس، روی-سوپراکسید دیسموتازpolychlorobiphenyl - پلی کلروفیل بفنیلreduced glutathione - کاهش گلوتاتیونglutathione S-transferase - گلوتاتیون S-ترانسفرازglucose-6-phosphate - گلوکز 6-فسفاتglucose-6-phosphate dehydrogenase - گلوکز 6-فسفات دهیدروژناز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The mutagenicities of various carcinogens induced by liver microsomes are increased in the presence of liver cytosol in rodents. It still remains, however, to be clarified which factor or factors in the cytosol enhance(s) the microsome-mediated mutagenicities. In the present study, we sought to identify the enhancing factor in liver cytosol prepared from rats using the microsome-mediated Salmonella mutagenicity induced by 2-amino-6-methyldipyrido [1,2-a:3â²,2â²-d] imidazole (Glu-P-1). By a series of chromatographic steps, we purified a 16-kDa protein on SDS-PAGE from the cytosol of rat livers. Partial amino acid sequences of this protein revealed that the 16-kDa protein was copper, zinc-superoxide dismutase (CuZn-SOD). The purified CuZn-SOD enhanced the microsome-mediated mutagenicities of several heterocyclic amines and aromatic amines. Furthermore, bovine and human CuZn-SOD also enhanced the microsome-mediated mutagenicity of Glu-P-1. The CuZn-SOD caused an increase in the mutagenicity of N-hydroxylated Glu-P-1 formed from Glu-P-1 by the microsomes, although CuZn-SOD did not affect either the formation or the stability of the N-hydroxylated derivative. These findings suggest that the enhancing cytosol factor for the mutagenicity of Glu-P-1 is CuZn-SOD, which stimulates the mutagenicity of N-hydroxylated Glu-P-1 without changing its metabolism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mutation Research/Genetic Toxicology and Environmental Mutagenesis - Volume 653, Issues 1â2, 31 May 2008, Pages 14-22
Journal: Mutation Research/Genetic Toxicology and Environmental Mutagenesis - Volume 653, Issues 1â2, 31 May 2008, Pages 14-22
نویسندگان
Hiroaki Nii, Masato Tsutsui, Jun Kondo, Yumiko Toyohira, Susumu Ueno, Nobuyuki Yanagihara,