Volumetric and transport properties of betaine hydrochloride drug in aqueous uracil solutions at T = (298.15–318.15) K

• Densities and viscosities of betaine hydrochloride in aqueous uracil solutions measured.
• Apparent molar volume (ϕV)(ϕV) and standard molar volume ϕV0 determined.
• Viscosity B-coefficient was determined.
• Effect of molality, solute structure and temperature analyzed in terms of ion–ion and ion–solvent interactions.
• Betaine hydrochloride behaves as a long range structure maker.

Apparent molar volumes and viscosity B-coefficients for betaine hydrochloride in aqueous uracil solutions were determined from solution densities and viscosities measured at T = (298.15–318.15) K and at pressure p = 101 kPa as a function of betaine hydrochloride concentrations. The standard partial molar volumes ϕV0 and slopes SV∗ obtained from Masson equation were interpreted in terms of solute–solvent and solute–solute interactions, respectively. Solution viscosities were analyzed using Jones–Dole equation and the viscosity A and B   coefficients discussed in terms of solute–solute and solute–solvent interactions, respectively. The standard volume of transfer ΔtϕV0 and viscosity B  -coefficients of transfer (ΔtB)(ΔtB) of betaine hydrochloride from water to aqueous uracil solutions were derived to understand various interactions in the ternary solutions. The activation parameters of viscous flow for the studied solutions were discussed in terms of transition state theory. The structure making or breaking ability of betaine hydrochloride was discussed in terms of the sign of dϕE0/dTP.

Figure optionsDownload as PowerPoint slide