کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
215656 | 1426259 | 2012 | 8 صفحه PDF | دانلود رایگان |
We found that addition of 3-[4-(2-hydroxyethyl)-1-piperazinyl]propane sulfonic acid (EPPS) induces phase separation of (acetonitrile + water) mixtures and (acetone + water) mixtures at T = 298 K, although these organic solvents are miscible with water at any mixing ratio. The phase diagrams of (acetonitrile + water + EPPS) and (acetone + water + EPPS) systems showed that the phase separation takes place in a wide range of the organic solvent mass fractions, 0.25 < w < 0.95. The solubility limits of EPPS buffer before the phase separations were determined by densimetry. The (liquid + liquid) equilibrium (LLE) and (solid + liquid + liquid) equilibrium (SLLE) data were measured for these ternary systems at T = 298.15 K under atmospheric pressure. The EPPS can be used as an auxiliary agent to pass over the (acetonitrile + water) azeotrope. The phase boundary data of the different specific regions in the phase diagrams were fitted to an empirical equation and the effective excluded volume (EEV) model. The experimental LLE data (tie-lines) were found to be thermodynamically consistent according to Othmer–Tobias equation. The NRTL activity coefficient model was used to correlate the experimental tie-lines. Molecular mechanical and semi-empirical quantum-mechanical calculations were used to study the intermolecular interactions between EPPS buffer and acetonitrile/acetone in gas phase and in water under the periodic boundary conditions. Then, we proposed a possible mechanism of EPPS-induced phase separation of the investigated systems.
Figure optionsDownload as PowerPoint slideHighlights
► EPPS buffer-induced phase separation of water with acetonitrile or acetone mixtures.
► Phase diagrams of EPPS + water + acetonitrile or acetone are prepared.
► (Liquid + liquid) equilibrium data are correlated satisfactorily with the NRTL model.
► Molecular mechanical and semi-empirical quantum-mechanical calculations were made.
Journal: The Journal of Chemical Thermodynamics - Volume 54, November 2012, Pages 134–141