Intramucosal follicular lymphoma in the terminal ileum with nodal involvement

Primary gastrointestinal follicular lymphoma (FL) is rare, and there is only one previously reported case with lymphoma cells confined within the mucosa, a stage IE disease. We present the second case of primary intramucosal FL located in the terminal ileum, with focal nodal involvement in a 47-year-old male. This unusual case demonstrates that even an intramucosal FL exhibits the potential for nodal spread, which is evidence of lymphocytic trafficking within the lymphoid system.