کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2161328 1090912 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Radiation-induced effects on gene expression: An in vivo study on breast cancer
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Radiation-induced effects on gene expression: An in vivo study on breast cancer
چکیده انگلیسی

Background and PurposeBreast cancer is diagnosed worldwide in approximately one million women annually and radiation therapy is an integral part of treatment. The purpose of this study was to investigate the molecular basis underlying response to radiotherapy in breast cancer tissue.Material and MethodsTumour biopsies were sampled before radiation and after 10 treatments (of 2 Gray (Gy) each) from 19 patients with breast cancer receiving radiation therapy. Gene expression microarray analyses were performed to identify in vivo radiation-responsive genes in tumours from patients diagnosed with breast cancer. The mutation status of the TP53 gene was determined by using direct sequencing.Results and conclusionSeveral genes involved in cell cycle regulation and DNA repair were found to be significantly induced by radiation treatment. Mutations were found in the TP53 gene in 39% of the tumours and the gene expression profiles observed seemed to be influenced by the TP53 mutation status.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Radiotherapy and Oncology - Volume 80, Issue 2, August 2006, Pages 230–235
نویسندگان
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