Effect of temperature on the dilution enthalpies of α,ω-amino acids in aqueous solutions

Dilution enthalpies of aqueous solutions of 3-amino propanoic acid, 4-amino butanoic acid, 5-amino pentanoic acid, and 6-amino hexanoic acid were determined at T = (293.15, 298.15, 303.15, and 308.15) K using an LKB flow microcalorimeter. The homotactic interaction coefficients were obtained according to the McMillan–Mayer theory from the experimental data. For all the systems studied, the dilution of α,ω-amino acids in water is an exothermic process; the pair coefficients have positive values which increases with chain length. The obtained values of the interaction coefficients are interpreted in terms of solute–solvent and solute–solute interactions and are used as indicative of hydrophobic behavior of the amino acid studied.

► The dilution of 3-amino propanoic acid, 4-amino butanoic acid, 5-amino pentanoic acid, and 6-amino hexanoic acid in water is an exothermic process at T = (293.15, 298.15, 303.15, and 308.15) K.
► The limiting experimental slopes of the enthalpies of dilution with respect to the molality change ΔmΔm, are negative suggesting that the solutes interact with water primarily through their alkyl groups.
► The value of the pairwise coefficient is positive at the temperatures considered, and the magnitude increases linearly with the number of methylene groups.
► The comparison between the pairwise interaction coefficients for α,ω-amino acids and α-amino acids shows that the change in the enthalpic interaction coefficient is related to the relative position of the polar groups.