کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2167066 1092304 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Exploring the role of short-course cyclosporin a therapy in preventing homograft valve calcification after transplantation
ترجمه فارسی عنوان
بررسی نقش سیکلوسپورین کوتاه مدت در جلوگیری از کلسیفیکاسیون سوپاپ هموگرافی بعد از پیوند
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی


• Observed morphological change of homograft valves after transplantation.
• Figured out the variation tendency of immunological rejection after transplantation.
• Measured the change of calcium content in homograft valves after transplantation.
• Explore the mechanism and effect of cyclosporin A in preventing calcification.

This study was designed to explore the role of short-course cyclosporin A therapy in preventing calcification. Homograft valves heterotopically allografted onto abdominal aorta from SD to Wistar rats. The expression of CD25, CD40L, CD71, calcium content and morphological change were observed. In control group, expression of immune indices got maximal at early stage postoperatively, and then gradually declined, remained at low level 12 weeks afterwards. In test group with Cyclosporin A, the expression of immune indices were lower than that of control group at 2–4 weeks postoperatively, but no significant difference was found 8 weeks afterwards. The calcification began from 4 weeks postoperatively, increased gradually and reached highest level at 12 weeks. In test group calcium content was much lower from 4 to 16 weeks postoperatively. It is concluded that cyclosporine A treatment can prevent calcification of homograft valves because it inhibited immune response at early stage after transplantation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 287, Issue 1, January 2014, Pages 36–45
نویسندگان
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