کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2167587 1092342 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
HIV-1 Nef associates with p22-phox, a component of the NADPH oxidase protein complex
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
HIV-1 Nef associates with p22-phox, a component of the NADPH oxidase protein complex
چکیده انگلیسی

Altered neutrophil function may contribute to the development of AIDS during the course of HIV infection. It has been described that Nef, a regulatory protein from HIV, can modulate superoxide production in other cells, therefore altered superoxide production in neutrophils from HIV infected patients, could be secondary to a direct effect of Nef on components of the NADPH oxidase complex. In this work, we describe that Nef, was capable of increasing superoxide production in human neutrophils. Furthermore, a specific association between Nef and p22-phox, a membrane component of the NADPH oxidase complex, was found. We propose that this association may reflect a capability of Nef to modulate by direct association, the enzymatic complex responsible for one of the most efficient innate defense mechanisms in phagocytes, contributing to the pathogenesis of the disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 263, Issue 2, 2010, Pages 166–171
نویسندگان
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