کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2167891 1092359 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vivo osteopontin-induced macrophage accumulation is dependent on CD44 expression
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
In vivo osteopontin-induced macrophage accumulation is dependent on CD44 expression
چکیده انگلیسی

In order to assess the role of osteopontin (OPN) in leukocyte accumulation in inflammatory conditions, native OPN and its thrombin cleaved form (OPN + Thr) were studied in vivo using a rodent subcutaneous air pouch model (AP). Both forms of OPN-induced macrophage infiltration into the AP in wild-type mice. In animals lacking CD44, macrophage numbers were significantly reduced within the cavity, but cells still accumulated along the subcutaneous lining. In animals lacking endogenous OPN, no differences were found in exogenous OPN-induced macrophage accumulation, although macrophage exhibited increased α4 integrin expression. These studies reveal that both OPN and OPN + Thr attract macrophages in vivo through CD44.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 254, Issue 1, 2008, Pages 56–62
نویسندگان
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