کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2170818 1549506 2007 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pharmacogenomics of Type I interferon therapy: A survey of response-modifying genes
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Pharmacogenomics of Type I interferon therapy: A survey of response-modifying genes
چکیده انگلیسی

Interferon-β (IFN-β) is routinely prescribed as an immunomodulatory treatment for multiple sclerosis (MS), but is associated with variable clinical efficacy. Ideally an early predictor of response status would allow more rational provision of this therapy. Both pharmacogenomic and expression analysis have highlighted IFN-β regulated genes which may influence treatment efficacy. In this review we have summarized and discussed the main genes identified by these studies in MS patients, and supplemented this with data from similar studies of Type I IFN treatment in hepatitis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine & Growth Factor Reviews - Volume 18, Issues 3–4, June–August 2007, Pages 211–222
نویسندگان
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