کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2173132 | 1093697 | 2013 | 13 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The TAO kinase KIN-18 regulates contractility and establishment of polarity in the C. elegans embryo The TAO kinase KIN-18 regulates contractility and establishment of polarity in the C. elegans embryo](/preview/png/2173132.png)
Cell polarity is crucial for many aspects of cell and developmental biology. Cytoskeleton remodeling plays an essential role in the establishment of cell polarity. In the Caenorhabditis elegans one-cell embryo, while the actomyosin cytoskeleton is required for asymmetric localization of the PAR proteins, anterior PAR proteins exert a feedback regulation on contractility. Here we identify the TAO kinase KIN-18 as a regulator of cortical contractility in the early embryo. KIN-18 negatively regulates cortical contractions in a RHO-1 dependent manner and regulates RHO-1 cortical localization. KIN-18 contributes to polarity establishment by regulating the position of the boundary between anterior and posterior PAR proteins. Although KIN-18 is involved in polarity establishment, depletion of KIN-18 restores contractions in a par-3 mutant indicating that kin-18 is epistatic to par-3. We suggest a model in which KIN-18 provides a link between the cytoskeleton remodeling and polarity machineries, uncovering a role for TAO kinases in the regulation of cell polarity.
► The TAO kinase KIN-18 regulates C. elegans embryonic cortical contractility.
► KIN-18 negatively regulates cortical contractions in a RHO-1 dependent manner.
► KIN-18 regulates RHO-1 cortical localization.
► KIN-18 regulates the position of the boundary between PAR proteins.
► KIN-18 plays a role in polarity establishment.
Journal: Developmental Biology - Volume 373, Issue 1, 1 January 2013, Pages 26–38