Characterization of PEDOT:PSS-reduced graphene oxide@Pd composite electrode and its application in voltammetric determination of vitamin K3

• PEDOT:PSS-reduced graphene oxide @ Pd composite for the fabrication of sensor
• The as-obtained sensor displayed the synergistically enhanced electrocatalytic ability and superior sensing performance.
• The proposed method was employed for voltammetric determination of vitamin K3 in animal blood and feed samples.

Vitamin K3 (VK3), a synthetic blood coagulation vitamin with fat-solubility, easily results in side-effect in animal body due to its toxicity and improper addition of animal feedstuffs. In this study, a novel sensor based on glassy carbon electrode (GCE) modified with a conducting polymer-both nano-noble metals and two-dimensional nano-carbon composite consisting of poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS), carboxymethyl cellulose (CMC) and reduced graphene oxide@palladium (rGO@Pd) was successfully used for the voltammetric detection of VK3 in animal blood and feedstuff samples. Under the optimized conditions, PEDOT:PSS-CMC-rGO@Pd/GCE/GCE displayed the excellent synergistically electrocatalytic ability for the electrochemical oxidation-reduction of VK3, which exhibited a good voltammetric response for VK3 in the concentration range from 4 × 10− 7 to 9 × 10− 5 M, with a limit of detection of 1.4 × 10− 8 M. Furthermore, a facile preparation, high sensitivity, good selectivity, superior sensing stability, and satisfactory practicability of PEDOT:PSS-CMC-rGO@Pd/GCE/GCE for sensing VK3 suggested that the potential applicability of PEDOT:PSS-CMC-rGO@Pd provided a promising electrochemical sensing platform for the determination of VK3 in pharmaceutical and feed inspection.

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