Development of an electrode modified on the basis of carbon nanoparticles and reduced graphene oxide for simultaneous determination of isoproterenol, uric acid and tryptophan in real samples

• A carbon paste electrode was modified with a novel hydroquinone compound.
• Electrocatalytic oxidation of isoproterenol was studied.
• The electrochemical sensor used for the detection of isoproterenol.
• The sensor used to measure IP in isoproterenol ampule, urine and human blood serum.
• The high sensitivity and ease of preparation of the electrode are the advantages of the proposed electrode.

In this research, the electrochemical properties of a carbon paste electrode modified by synthesized carbon nanoparticles (CNPs), reduced graphene oxide (RGO), and a novel derivative of hydroquinone, (Z)-4-(naphthalen-1-ylimino methyl) benzene-1, 2-diol, (NYB) were studied by cyclic voltammetry. The modified electrode was used as an electrochemical sensor for catalytic oxidation of isoproterenol (IP), and it exhibited an excellent electrocatalytic activity for IP with a good electrochemical performance, low overpotential and high conductivity. It was found that under optimum conditions (pH = 7.0) in cyclic voltammetry, the oxidation potential of IP would decrease to about 324 mV at the modified electrode as compared to an unmodified carbon paste electrode. Differential pulse voltammetry (DPV) exhibited two linear dynamic ranges of 0.5 to 80.0 μM and 80.0 to 1000.0 μM for IP. Also, the selectivity of the prepared electrochemical sensor was checked for determination of IP in the presence of uric acid (UA) and Tryptophan (Try). The detection limit for IP was found to be 0.065 μM.

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