کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2182007 1550058 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neuronal expression of class 6 semaphorins in zebrafish
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Neuronal expression of class 6 semaphorins in zebrafish
چکیده انگلیسی

Semaphorins are a large family of guidance molecules identified by an extracellular SEMA domain. Classes 1 and 2 are derived from invertebrates, classes 3–7 are vertebrate and class 8 (v) are viral semaphorins. Class 6 semaphorins are reported to have a wide variety of roles including in axon guidance, transcriptional regulation and cancer. Here we report the identification and expression of four class 6 semaphorins (6A, 6Ba, 6Bb and 6Dl) in three stages of larval development in zebrafish (24, 48 and 72 hours postfertilization). Our data indicate that each of the class 6 semaphorins shows a distinct pattern of expression in the developing nervous system that is dynamic over the first 3 days of embryonic development. These data suggest that the individual class 6 semaphorins have diverse roles in nervous system development.


► Class 6 semaphorins show distinct and dynamic expression in early development.
► Sema6A is expressed in retinal ganglion cells, optic tectum and midbrain.
► Sema6Ba is expressed in hindbrain neurons, retinal ganglion cells and midbrain.
► Sema6Bb is expressed in the vagal ganglia, intermediate hypothalamus, and retina.
► Sema6D is expressed in the lens, dorsal midbrain, tectum, and vagal ganglia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene Expression Patterns - Volume 12, Issues 3–4, March–April 2012, Pages 117–122
نویسندگان
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