کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2182488 | 1095466 | 2006 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Duplicate sfrp1 genes in zebrafish: sfrp1a is dynamically expressed in the developing central nervous system, gut and lateral line
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کلمات کلیدی
sFRPPrimordiumNeuroectodermWntTelencephalonNeuromastfrizzledPronephros - PronephriumEndoderm - اندودرمBlastoderm - بلستودرمEnhancer trap - تله تقویت کنندهLateral line - خط جانبیCNS - دستگاه عصبی مرکزیSomite - سومیYolk syncytial layer - لایه یون سیکسیتی یولکPronephric duct - مجرای صفراوی PronephricParaxial mesoderm - مزودرم مضاعفMidbrain - میانمغز، مزانسفالHindbrain - هیدروپینSecreted frizzled-related protein - پروتئین مرتبط با فروکتوز جدا شده استEye - چشمGastrula - گاسترولاTegmentum - گرهGut - گل سرخDanio rerio - گورخرماهیZebrafish - گورخرماهیEAR - گوش
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The secreted frizzled-related proteins (Sfrp) are a family of soluble proteins with diverse biological functions having the capacity to bind Wnt ligands, to modulate Wnt signalling, and to signal directly via the Wnt receptor, Frizzled. In an enhancer trap screen for embryonic expression in zebrafish we identified an sfrp1 gene. Previous studies suggest an important role for sfrp1 in eye development, however, no data have been reported using the zebrafish model. In this paper, we describe duplicate sfrp1 genes in zebrafish and present a detailed analysis of the expression profile of both genes. Whole mount in situ hybridisation analyses of sfrp1a during embryonic and larval development revealed a dynamic expression profile, including: the central nervous system, where sfrp1a was regionally expressed throughout the brain and developing eye; the posterior gut, from the time of endodermal cell condensation; the lateral line, where sfrp1a was expressed in the migrating primordia and interneuromast cells that give rise to the sensory organs. Other sites included the blastoderm, segmenting mesoderm, olfactory placode, developing ear, pronephros and fin-bud. We have also analysed sfrp1b expression during embryonic development. Surprisingly this gene exhibited a divergent expression profile being limited to the yolk syncytium under the elongating tail-bud, which later covered the distal yolk extension, and transiently in the tail-bud mesenchyme. Overall, our studies provide a basis for future analyses of these developmentally important factors using the zebrafish model.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene Expression Patterns - Volume 6, Issue 8, 2 October 2006, Pages 835-842
Journal: Gene Expression Patterns - Volume 6, Issue 8, 2 October 2006, Pages 835-842
نویسندگان
Guillaume Pézeron, Isabelle Anselme, Mary Laplante, Staale Ellingsen, Thomas S. Becker, Frédéric M. Rosa, Patrick Charnay, Sylvie Schneider-Maunoury, Philippe Mourrain, Julien Ghislain,