Keywords: lung disease; regenerative medicine; stem cells; AECII; type II alveolar epithelial cell; ALI; air-liquid interface; BASC; bronchioalveolar stem cell; BC; basal cell; CC; club cell; EGFR; epidermal growth factor receptor; FZD4; Frizzled; IPF; idiopathic p
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Keywords: 5-FU; 5-Fluorouracil; ABCB5; ATP-binding cassette sub-family B member 5; ABCC2; ATP-binding cassette sub-family C member 2; ABCG2; ATP-binding cassette sub-family G member 2; ACs; Anthocyanins; ALDH; aldehyde dehydrogenase; AML; acute myeloid leukemia; AP
Keywords: ALK1; activin receptor-like kinase1; ANG/Ang; angiopoietin; Bcl-xL; b-cell lymphoma-extra large; BM; bone marrow; BMDCs; bone marrow derived cells; BMP; bone morphogenetic protein; Bv8; bombina variagata peptide 8; CAFs; cancer/carcinoma associated fibrob
Keywords: BPH; benign prostate hyperplasia; CRD; cysteine-rich domain; DKKs; Dickkopfs; DNMTs; DNA methyltransferases; Fz; Frizzled; HCC; hepatocellular carcinoma; HCV; hepatitis C virus; LC; liver cirrhosis; LRP-5/6; low-density lipoprotein receptor-related protei
Keywords: Intestinal Epithelial Barrier; Intestinal Inflammation; Immune-Epithelial Crosstalk; BMP; bone morphogenic protein; CD; Crohn's disease; Fz; frizzled; HD; humans α-defensin; IBD; inflammatory bowel disease; IECs; intestinal epithelial cells; IL; interleu
Keywords: TERT; telomerase reverse transcriptase; RNP; ribonucleoprotein; TR; telomerase RNA; CSCs; cancer stem cells; TEN; telomerase essential N-terminal; TRB; TERT RNA-binding; RT; reverse transcriptase; CTE; C-terminal extension; DAT; dissociates activities of
Keywords: Amphioxus; Frizzled; Wnt receptor; Gene expression patterns; Embryonic development;
A cytoskeletal activator and inhibitor are downstream targets of the frizzled/starry night planar cell polarity pathway in the Drosophila epidermis
Keywords: Planar cell polarity; Frizzled; Actin; Drosophila;
Antagonistic role of Klotho-derived peptides dynamics in the pancreatic cancer treatment through obstructing WNT-1 and Frizzled binding
Keywords: Klotho; WNT-1; CRDs; Frizzled;
Dually modified transmembrane proteoglycans in development and disease
Keywords: ActR; activin type receptor; ALK; activin receptor like kinase; AV; atrioventricular cushion; BMP; bone morphogenetic protein; BMPR; bone morphogenetic protein receptor; C1; conserved domain 1; C2; conserved domain 2; Cdc42; control protein 42 homolog; CS
Cftr Modulates Wnt/β-Catenin Signaling and Stem Cell Proliferation in Murine Intestine
Keywords: Cystic Fibrosis; Dishevelled; Organoids; Intracellular pH; Neoplasia; CBC; crypt-base columnar cell; CCH; carbachol; CF; cystic fibrosis; Cftr; cystic fibrosis transmembrane conductance regulator; DEP; Dishevelled, Egl-10, and Pleckstrin; Dvl; Dishevelled
Hsa-miR-11181 regulates Wnt signaling pathway through targeting of APC2 transcripts in SW480 cell line
Keywords: Wnt; wingless-type; APC; adenomatosis polyposis coli; Axin; axis inhibition protein; FZ; frizzled; LEF; lymphoid enhancer binding factor; TCF; T-cell-specific factor; GSK3-β; glycogen synthase kinase 3-beta; TRE; transcriptional response element; Dsh; di
The WNT signaling pathways in wound healing and fibrosis
Keywords: ADP; adenosine diphosphate; APC; adenomatosis polyposis coli; CBP; cyclic AMP response element binding protein; CCL4; carbon tetrachloride; CK-1; casein kinase 1; DKK; dickkopf; EVI; evenness interrupted; FZD; frizzled; GSK-3; glycogen synthase kinase 3;
Deubiquitylating enzymes as cancer stem cell therapeutics
Keywords: Protein-IPSC; protein-induced pluripotent stem cells; CSCs; cancer stem cells; DUBs; deubiquitylating enzymes; ESCs; embryonic stem cells; PTMs; post-translational modifications; AML; acute myelogenous leukemia; USP/UBP; ubiquitin-specific processing prot
WNT receptor signalling in lung physiology and pathology
Keywords: ABC; active β-catenin/non-phosphorylated β-catenin; APC; adenomatous polyposis coli; ATI; alveolar epithelial type I cell; ATII; alveolar epithelial type II cell; AXIN; axis inhibition protein; CBR2; carbonyl reductase 2; CK1; casein kinase 1; CELSR1; c
Emerging role and therapeutic implication of Wnt signaling pathways in liver fibrosis
Keywords: α-SMA; α-smooth muscle actin; ALD; alcoholic liver disease; APC; adenomatous polyposis coli; CamKII; calcium sensitive enzymes calmodulin kinase II; CK1; casein kinase 1; CLD; chronic liver disease; COX-2; cyclooxygenase-2; CTGF; connective tissue growt
Comparative analysis of the neurula transcriptomes of two species of flatfishes: Platichthys stellatus and Paralichthys olivaceus
Keywords: BMP; Bone Morphogenetic Protein; BMPR; Bone Morphogenetic Protein Receptor; BLAST; Basic Local Alignment Search Tool; ERBB; Erb-b2 Receptor Tyrosine Kinase; FGF; Fibroblast Growth Factor; FGFR; Fibroblast Growth Factor Receptor; FZ; Frizzled; HOXB1B; Home
Prenatal high sucrose intake affected learning and memory of aged rat offspring with abnormal oxidative stress and NMDARs/Wnt signaling in the hippocampus
Keywords: AD; Alzheimer's disease; DKK1; Dickkopf-related protein 1; FINS; fasting plasma insulin; HS; high sucrose; FPG; fasting plasma glucose concentration; FZD; Frizzled; Homa-IR; insulin resistance index; LRP5/6; low-density lipoprotein-related protein recep
Extrinsic control of Wnt signaling in the intestine
Keywords: APC; Adenomatous polyposis coli; CAC; Colitis-associated cancer; CBC; Crypt base columnar; DKK; Dickkopf-related protein; FZD; Frizzled; GSK; Glycogen synthase kinase; IBD; Inflammatory bowel diseases; IFN; Interferon; IL; Interleukin; LGR; Leucine-rich r
Original ArticleSRI36160 is a specific inhibitor of Wnt/β-catenin signaling in human pancreatic and colorectal cancer cells
Keywords: Wnt signaling; Benzimidazole; Niclosamide; Targeted therapy; Drug discovery; APC; adenomatous polyposis coli; CIC; cancer initiating cell; Fzd; frizzled; LRP6; low-density lipoprotein receptor-related protein-6; PDAC; pancreatic ductal adenocarcinoma; PI;
WNT/β-catenin pathway modulates the TNF-α-induced inflammatory response in bronchial epithelial cells
Keywords: TNF-α; WNT; β-catenin; Inflammation; Bronchial epithelial cell; COPD; chronic obstructive pulmonary disease; Dvl; disheveled; Fz; frizzled; GSK; glycogen synthase kinase; IL; interleukin; LRP; lipoprotein receptor-related protein; MCP; monocyte chemoatt
Characterization of secondary structure and lipid binding behavior of N-terminal saposin like subdomain of human Wnt3a
Keywords: Canonical Wnt signal transduction; Circular dichroism spectroscopy; Limited proteolysis; Liposomes; Saposin; Wnt3a; NT; N-terminal; CT; C-terminal; SAPLIP; saposin-like protein; SLD; saposin-like subdomain; SLD, NT-SLD(nh); N-terminal saposin-like subdoma
Analysis of the expression of the Wnt family of proteins and its modulatory role on cytokine expression in non activated and activated astroglial cells
Keywords: CNS; central nervous system; BBB; blood brain barrier; Fz; Frizzled; ROR; receptor tyrosine kinase-like orphan receptor; PTK7; protein tyrosine kinase 7; PCP; planar cell polarity; Wif; Wnt inhibitory factor; Dkk; Dickkopf; sFRP; secreted Frizzled-related
FZD10-Gα13 signalling axis points to a role of FZD10 in CNS angiogenesis
Keywords: DMR; dynamic mass redistribution; DVL; dishevelled; dcFRAP; dual color fluorescence recovery after photobleaching; FRET; Förster resonance energy transfer; FZD; Frizzled; WNT; Wingless/Int-1 family of proteins; LRP5/6; Low Density Lipoprotein Receptor-Re
Mining Naïve Rabbit Antibody Repertoires by Phage Display for Monoclonal Antibodies of Therapeutic Utility
Keywords: mAb; monoclonal antibody; pAbs; polyclonal antibodies; IHC; immunohistochemistry; ELISA; enzyme-linked immunosorbent assay; NGS; next-generation sequencing; aa; amino acid; Ig; immunoglobulin; Fz; frizzled; Kr; kringle; BC; breast cancer; CAR-T; chimeric
Lawsone derivatives target the Wnt/β-catenin signaling pathway in multidrug-resistant acute lymphoblastic leukemia cells
Keywords: ABC; ATP-binding cassette; ALL; acute lymphoblastic leukemia; CRD; cysteine-rich domain; DMSO; dimethyl sulfoxide; FZD; Frizzled receptor; IC50,; 50% inhibition concentration; LPR5; lipoprotein-related protein 5; MDR; multidrug resistance; PDB; protein da
The tyrosine Y2502.39 in Frizzled 4 defines a conserved motif important for structural integrity of the receptor and recruitment of Disheveled
Keywords: Disheveled; DVL2; Frizzled; FZD4; GNA12; GNA13;
Wnt, Frizzled, and sFRP gene expression patterns during gastrulation in the starfish Patiria (Asterina) pectinifera
Keywords: Starfish; Embryo; Expression pattern; Wnt; Frizzled; sFRP
Alteration of canonical and non-canonical WNT-signaling by crystalline silica in human lung epithelial cells
Keywords: ACTA2; Actin, alpha, smooth muscle; ANGPTL4; Angiopoietin-like 4; ANOVA; Analysis of variance; AXIN; Axis inhibition protein; BMP; Bone morphogenic protein; BMPR1B; BMP receptor 1B; CACNA2D3; Calcium channel, voltage-dependent, alpha 2/delta subunit 3; CC
ReviewWnt signaling pathway in cardiac fibrosis: New insights and directions
Keywords: TCF; T-cell factor; LEF; Lymphocyte enhancing factor; ECM; Extracellular matrix; α-SMA; α-smooth muscle actin; Fz; Frizzled; TGF-β1; Transforming growth factor β1; PDGF; Platelet-derived growth factor; FGF; Fibroblast growth factor; APC; Adenomatous p
“Fibrous nests” in human hepatocellular carcinoma express a Wnt-induced gene signature associated with poor clinical outcome
Keywords: α-SMA; alpha smooth muscle actin; DKK; Dickkopf; ECM; extracellular matrix; FNH; focal nodular hyperplasia; FZD; frizzled; GSE; gene expression series; GSK3B; glycogen synthase kinase 3 beta; HCC; hepatocellular carcinoma; iPS cells; induced pluripotent
Requirement of Gαq/Gα11 Signaling in the Preservation of Mouse Intestinal Epithelial Homeostasis
Keywords: Paneth Cell; Intermediate Cell; Wnt; Gnaq; Gna11; Atoh1; atonal homolog 1; BrdU; bromodeoxyuridine; Defa1; defensin α1; Dll1; delta-like 1; DSS; dextran sodium sulfate; FGF; fibroblast growth factor; Fzd; frizzled; Hes; hairy/enhancer of split; IEC; inte
Wnt signaling in bone and muscle
Keywords: Wnt; Frizzled; Osteoblasts; Satellite stem cells; Muscle; Bone
Research ArticleComplete response of Ctnnb1-mutated tumours to β-catenin suppression by locked nucleic acid antisense in a mouse hepatocarcinogenesis model
Keywords: HCC; hepatocellular cancer; LNA; locked nucleic acid; DEN/PB; diethylnitrosamine and phenobarbital; GSK-3β; glycogen synthase kinase-3β; APC; Adenomatous polyposis coli; Fzd; Frizzled; LRP; low-density lipoprotein receptor related protein; CREB; cAMP re
Identification of 2-aminopyrimidine derivatives as inhibitors of the canonical Wnt signaling pathway
Keywords: APC; adenomatous polyposis coli; CK1; casein kinase-1; CYP3A4; Cytochrome P450 3A4; FPSA; fractional polar surface area; Fz; frizzled; GSK3; glycogen synthase kinase 3; LEF; lymphoid enhancer-binding factor; LRP; lipoprotein receptor-related protein; MW;
Therapeutic targets in the Wnt signaling pathway: Feasibility of targeting TNIK in colorectal cancer
Keywords: Colorectal cancer; Cancer stem cell; Wnt signaling; Traf2- and Nck-interacting kinase (TNIK); Molecular targeting therapy; ABC; ATP-binding cassette; APC; adenomatous polyposis coli; CBP; cAMP response element binding protein (CREB)-binding protein; CK; c
A novel Gynostemma pentaphyllum saponin and its adipogenesis inhibitory effect through modulating Wnt/β-catenin pathway and cell cycle in mitotic clonal expansion
Keywords: aP2; adipocyte protein 2; C/EBPα; CCAAT/enhancer-binding protein α; C/EBPβ; CCAAT enhancer-binding protein β; C/EBPδ; CCAAT/enhancer-binding protein δ; CHOP-10; C/EBP homologous protein; DVL; disheveled; ERK; extracellular signal-regulated kinase; F
Wnt pathway in Dupuytren disease: connecting profibrotic signals
Keywords: cDNA; complementary DNA; Fzd; Frizzled; HDF; human dermal fibroblasts; HPF; high power field; LRP; low-density lipoprotein receptor-related protein; siRNA; small interfering RNA; TGF; transforming growth factor; WISP1; Wnt1-inducible secreted protein 1;
Structure-activity relationship and properties optimization of a series of Quinazoline-2,4-diones as inhibitors of the canonical Wnt pathway
Keywords: Wnt pathway; β-catenin; Small molecule; Structure-activity relationship; Glioblastoma; Fz; Frizzled; LRP; lipoprotein receptor-related protein; ACN; acetonitrile; APC; adenomatous polyposis coli; B/P; brain to plasma ratio; CDI; N,Nâ²-carbonyl-diimida
Novel homozygous mutations in the WNT10B gene underlying autosomal recessive split hand/foot malformation in three consanguineous families
Keywords: WNT10B; wingless-type MMTV integration site family, member 10B; SHFM; Split hand foot malformation; TP63; tumor protein p63; DLX5; distal-less homeobox 5; bp; base pair; EDTA; Ethylene diamine tetra acetic acid; PCR; Polymerase Chain Reaction; cDNA; compl
Assessment of Frizzled 6 membrane mobility by FRAP supports G protein coupling and reveals WNT-Frizzled selectivity
Keywords: 7TM; seven transmembrane spanning; A1R; adenosine A1 receptor; DVL; disheveled; FRAP; fluorescence recovery after photobleaching; FZD; Frizzled; GFP; green fluorescent protein; GPCR; G protein-coupled receptor; NECA; 5â²-N-ethylcarboxamidoadenosine; NEM;
Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells
Keywords: 4E-BP1; eukaryotic initiation factor 4E binding protein 1; AMPK; 5â²-AMP-activated protein kinase; APC; adenomatous polyposis coli; CK1; casein kinase 1; CM; conditioned medium; eIF4E; eukaryotic initiation factor 4E; GSK3β; glycogen synthase kinase-3β
LRP6 dimerization through its LDLR domain is required for robust canonical Wnt pathway activation
Keywords: Canonical Wnt pathway; LRP5/6; Frizzled; Dimer; FPLC;
Wnt5a: A player in the pathogenesis of atherosclerosis and other inflammatory disorders
Keywords: Wnt5a; Macrophages; Inflammation; Atherosclerosis; Inflammatory disorders; Fz; frizzled; LRP; lipoprotein receptor-related protein; Ror2; receptor tyrosine kinase-like orphan receptor; DSH; disheveled; CaMKII; calmodulin dependent protein kinase II; PKC;
Sustained behavioral effects of lithium exposure during early development in zebrafish: Involvement of the Wnt-β-catenin signaling pathway
Keywords: DPF; days post-fertilization; Fz or FZd; frizzled; GSK-3; Glycogen synthase kinase-3; HPF; hours post-fertilization; IMPase; Inositol Monophosphatase; LiCl; Lithium Chloride; LRP; Lipoprotein receptor related protein; RT-qPCR; Quantitative Reverse Transcr
Wnt/β-catenin signaling regulates follicular development by modulating the expression of Foxo3a signaling components
Keywords: APC; adenomatosis polyposis coli; CTNNB1; β-catenin; DMSO; dimethylsulfoxide; CYP11A1; P450 cholesterol side chain cleavage; CYP19A1; cytochrome P450 aromatase; FBS; fetal bovine serum; Foxo; Forkhead box O; FZD; frizzled; GSK3β; glycogen synthase kinas
Is Alzheimer's disease related to metabolic syndrome? A Wnt signaling conundrum
Keywords: AMPK; AMP-activated protein kinase; STAT; activator of transcription; AGE; advanced glycation end products; AD; Alzheimer's disease; APP; amyloid precursor protein; Aβ; amyloid-β peptide; ACE; angiotensin converting enzyme; Ang I; angiotensin I; AR-II;
Transglutaminase 2 as a novel activator of LRP6/β-catenin signaling
Keywords: Fzd; Frizzled; LRP5/6; LRP5 or LRP6; APC; Adenomatosis Polyposis Coli; GSK3; Glycogen Synthase Kinase 3; TG2; Tissue transglutaminase; VSMCs; Vascular smooth muscle cells; TGases; Transglutaminases; ECM; Extracellular matrix; MEFs; Mouse embryonic fibrobl
The mechanisms of planar cell polarity, growth and the Hippo pathway: Some known unknowns
Keywords: Planar cell polarity; Growth; Gradients; Morphogens; Hippo; Fat; Dachsous; Wnt; Frizzled; Van Gogh; Starry night;
Wnt signaling in liver fibrosis: Progress, challenges and potential directions
Keywords: Liver fibrosis; Wnt signaling; Canonical Wnt signaling pathway; Hepatic stellate cell; Myofibroblastic transdifferentiation; HSCs; hepatic stellate cells; GFAP; glial fibrillary acidic protein; a-SMA; a-smooth muscle actin; TRAIL; tumor necrosis factor-re