کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10816144 | 1058543 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Transglutaminase 2 as a novel activator of LRP6/β-catenin signaling
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کلمات کلیدی
ECMVSMCsfrizzledFZDTG2ß-CateninGSK3MEFsAPCE. coliLRP5/6 - LRP5 / 6adenomatosis polyposis coli - آدنوماتوز پولیپوز کولیEscherichia coli - اشریشیا کُلیTissue transglutaminase - ترانس گلوتامیناز بافتیTransglutaminases - ترگلوتامینازهاVascular smooth muscle cells - سلول های عضلانی صاف عروقیExtracellular matrix - ماتریکس خارج سلولیmouse embryonic fibroblasts - موش فیبروبلاست جنینیglycogen synthase kinase 3 - گلیکوزین سنتاز کیناز 3
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Transglutaminase 2 as a novel activator of LRP6/β-catenin signaling Transglutaminase 2 as a novel activator of LRP6/β-catenin signaling](/preview/png/10816144.png)
چکیده انگلیسی
The β-catenin signaling axis is critical for normal embryonic development and tissue homeostasis in adults. We have previously shown that extracellular enzyme transglutaminase 2 (TG2) activates β-catenin signaling in vascular smooth muscle cells (VSMCs). In this study, we provide several lines of evidence that TG2 functions as an activating ligand of the LRP5/6 receptors. Specifically, we show that TG2 synergizes with LRP6 in the activation of β-catenin-dependent gene expression in Cos-7 cells. Interfering with the LRP5/6 receptors attenuates TG2-induced activation of β-catenin in Cos-7 cells. Further, we show that TG2 binds directly to the extracellular domain of LRP6, which is also able to act as a substrate for TG2-mediated protein cross-linking. Furthermore, inhibitors of TG2 protein cross-linking quench the observed TG2-induced β-catenin activation, implicating protein cross-linking as a novel regulatory mechanism for this pathway. Together, our findings identify and characterize a new activating ligand of the LRP5/6 receptors and uncover a novel activity of TG2 as an agonist of β-catenin signaling, contributing to the understanding of diverse developmental events and pathological conditions in which transglutaminase and β-catenin signaling are implicated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Signalling - Volume 25, Issue 12, December 2013, Pages 2646-2651
Journal: Cellular Signalling - Volume 25, Issue 12, December 2013, Pages 2646-2651
نویسندگان
S. Deasey, D. Nurminsky, S. Shanmugasundaram, F. Lima, M. Nurminskaya,