Keywords: AN; adult neurogenesis; AHR; aryl hydrocarbon receptor; APC; adenomatous polyposis coli; ARE; antioxidant responsive element; Axin; tumor suppressors Axin; aNSCs; adult neural stem cells; BMSCs; bone marrow-derived mesenchymal stem cells; BMPs; bone morph
مقالات ISI (ترجمه نشده)
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Keywords: 5-FU; 5-Fluorouracil; ABCB5; ATP-binding cassette sub-family B member 5; ABCC2; ATP-binding cassette sub-family C member 2; ABCG2; ATP-binding cassette sub-family G member 2; ACs; Anthocyanins; ALDH; aldehyde dehydrogenase; AML; acute myeloid leukemia; AP
Keywords: PASI; Psoriasis Area and Severity Index; IL; interleukin; fzd; frizzled receptors; IFN; interferon; ADAM; a disintegrin and metalloproteinase; EGF; epidermal growth factor; TGF; transforming growth factor; TPA; 12-o-tetradecanoyl phorbol-13-acetate; VEGF;
Keywords: ALK1; activin receptor-like kinase1; ANG/Ang; angiopoietin; Bcl-xL; b-cell lymphoma-extra large; BM; bone marrow; BMDCs; bone marrow derived cells; BMP; bone morphogenetic protein; Bv8; bombina variagata peptide 8; CAFs; cancer/carcinoma associated fibrob
Dually modified transmembrane proteoglycans in development and disease
Keywords: ActR; activin type receptor; ALK; activin receptor like kinase; AV; atrioventricular cushion; BMP; bone morphogenetic protein; BMPR; bone morphogenetic protein receptor; C1; conserved domain 1; C2; conserved domain 2; Cdc42; control protein 42 homolog; CS
The WNT signaling pathways in wound healing and fibrosis
Keywords: ADP; adenosine diphosphate; APC; adenomatosis polyposis coli; CBP; cyclic AMP response element binding protein; CCL4; carbon tetrachloride; CK-1; casein kinase 1; DKK; dickkopf; EVI; evenness interrupted; FZD; frizzled; GSK-3; glycogen synthase kinase 3;
Deubiquitylating enzymes as cancer stem cell therapeutics
Keywords: Protein-IPSC; protein-induced pluripotent stem cells; CSCs; cancer stem cells; DUBs; deubiquitylating enzymes; ESCs; embryonic stem cells; PTMs; post-translational modifications; AML; acute myelogenous leukemia; USP/UBP; ubiquitin-specific processing prot
WNT receptor signalling in lung physiology and pathology
Keywords: ABC; active β-catenin/non-phosphorylated β-catenin; APC; adenomatous polyposis coli; ATI; alveolar epithelial type I cell; ATII; alveolar epithelial type II cell; AXIN; axis inhibition protein; CBR2; carbonyl reductase 2; CK1; casein kinase 1; CELSR1; c
Original ArticleSRI36160 is a specific inhibitor of Wnt/β-catenin signaling in human pancreatic and colorectal cancer cells
Keywords: Wnt signaling; Benzimidazole; Niclosamide; Targeted therapy; Drug discovery; APC; adenomatous polyposis coli; CIC; cancer initiating cell; Fzd; frizzled; LRP6; low-density lipoprotein receptor-related protein-6; PDAC; pancreatic ductal adenocarcinoma; PI;
Extrinsic control of Wnt signaling in the intestine
Keywords: APC; Adenomatous polyposis coli; CAC; Colitis-associated cancer; CBC; Crypt base columnar; DKK; Dickkopf-related protein; FZD; Frizzled; GSK; Glycogen synthase kinase; IBD; Inflammatory bowel diseases; IFN; Interferon; IL; Interleukin; LGR; Leucine-rich r
Prenatal high sucrose intake affected learning and memory of aged rat offspring with abnormal oxidative stress and NMDARs/Wnt signaling in the hippocampus
Keywords: AD; Alzheimer's disease; DKK1; Dickkopf-related protein 1; FINS; fasting plasma insulin; HS; high sucrose; FPG; fasting plasma glucose concentration; FZD; Frizzled; Homa-IR; insulin resistance index; LRP5/6; low-density lipoprotein-related protein recep
Morphine administration induces change in anxiety-related behavior via Wnt/β-catenin signaling
Keywords: FZD; frizzled family of wnt receptor; BSA; bovine serum albumin; DMEM; dulbecco's modificationof eagle's medium; EPM; elevated plus maze test; β-catenin; Morphine; DKK1; Dendritic spine; Anxiety; HT22 cells;
Characterization of secondary structure and lipid binding behavior of N-terminal saposin like subdomain of human Wnt3a
Keywords: Canonical Wnt signal transduction; Circular dichroism spectroscopy; Limited proteolysis; Liposomes; Saposin; Wnt3a; NT; N-terminal; CT; C-terminal; SAPLIP; saposin-like protein; SLD; saposin-like subdomain; SLD, NT-SLD(nh); N-terminal saposin-like subdoma
FZD10-Gα13 signalling axis points to a role of FZD10 in CNS angiogenesis
Keywords: DMR; dynamic mass redistribution; DVL; dishevelled; dcFRAP; dual color fluorescence recovery after photobleaching; FRET; Förster resonance energy transfer; FZD; Frizzled; WNT; Wingless/Int-1 family of proteins; LRP5/6; Low Density Lipoprotein Receptor-Re
Regulation of Wnt signaling by protocadherins
Keywords: Pcdhs; protocadherins; EC; extracellular cadherin; PP1a; protein phosphatase 1a; WIRS; WRC interacting receptor sequence; FAK; focal adhesion kinase; PKC; protein kinase C; MMTV; mouse mammary tumor virus; Fzd; frizzleds; ICD; intracellular domain; Dvls;
Lawsone derivatives target the Wnt/β-catenin signaling pathway in multidrug-resistant acute lymphoblastic leukemia cells
Keywords: ABC; ATP-binding cassette; ALL; acute lymphoblastic leukemia; CRD; cysteine-rich domain; DMSO; dimethyl sulfoxide; FZD; Frizzled receptor; IC50,; 50% inhibition concentration; LPR5; lipoprotein-related protein 5; MDR; multidrug resistance; PDB; protein da
Alteration of canonical and non-canonical WNT-signaling by crystalline silica in human lung epithelial cells
Keywords: ACTA2; Actin, alpha, smooth muscle; ANGPTL4; Angiopoietin-like 4; ANOVA; Analysis of variance; AXIN; Axis inhibition protein; BMP; Bone morphogenic protein; BMPR1B; BMP receptor 1B; CACNA2D3; Calcium channel, voltage-dependent, alpha 2/delta subunit 3; CC
Syndecan4 coordinates Wnt/JNK and BMP signaling to regulate foregut progenitor development
Keywords: Syndecan; Extracellular matrix; Fibronectin; Fzd; Wnt; BMP; Foregut; Progenitor; Endoderm; Xenopus; hhex;
“Fibrous nests” in human hepatocellular carcinoma express a Wnt-induced gene signature associated with poor clinical outcome
Keywords: α-SMA; alpha smooth muscle actin; DKK; Dickkopf; ECM; extracellular matrix; FNH; focal nodular hyperplasia; FZD; frizzled; GSE; gene expression series; GSK3B; glycogen synthase kinase 3 beta; HCC; hepatocellular carcinoma; iPS cells; induced pluripotent
Requirement of Gαq/Gα11 Signaling in the Preservation of Mouse Intestinal Epithelial Homeostasis
Keywords: Paneth Cell; Intermediate Cell; Wnt; Gnaq; Gna11; Atoh1; atonal homolog 1; BrdU; bromodeoxyuridine; Defa1; defensin α1; Dll1; delta-like 1; DSS; dextran sodium sulfate; FGF; fibroblast growth factor; Fzd; frizzled; Hes; hairy/enhancer of split; IEC; inte
Targeting cancer stem cells in solid tumors by vitamin D
Keywords: CSC; Cancer stem cell; 1α,25(OH)2D3; 1α,25-dihydroxyvitamin D3; EpCAM; Epithelial cell adhesion molecule; PROM1; Prominin 1; CXCR4; C-X-C chemokine receptor type 4; SDF1; Stromal cell-derived factor 1; ALDH-1; Aldehyde dehydrogenease-1; EMT; Epithelial-
Research ArticleComplete response of Ctnnb1-mutated tumours to β-catenin suppression by locked nucleic acid antisense in a mouse hepatocarcinogenesis model
Keywords: HCC; hepatocellular cancer; LNA; locked nucleic acid; DEN/PB; diethylnitrosamine and phenobarbital; GSK-3β; glycogen synthase kinase-3β; APC; Adenomatous polyposis coli; Fzd; Frizzled; LRP; low-density lipoprotein receptor related protein; CREB; cAMP re
Therapeutic targets in the Wnt signaling pathway: Feasibility of targeting TNIK in colorectal cancer
Keywords: Colorectal cancer; Cancer stem cell; Wnt signaling; Traf2- and Nck-interacting kinase (TNIK); Molecular targeting therapy; ABC; ATP-binding cassette; APC; adenomatous polyposis coli; CBP; cAMP response element binding protein (CREB)-binding protein; CK; c
A novel Gynostemma pentaphyllum saponin and its adipogenesis inhibitory effect through modulating Wnt/β-catenin pathway and cell cycle in mitotic clonal expansion
Keywords: aP2; adipocyte protein 2; C/EBPα; CCAAT/enhancer-binding protein α; C/EBPβ; CCAAT enhancer-binding protein β; C/EBPδ; CCAAT/enhancer-binding protein δ; CHOP-10; C/EBP homologous protein; DVL; disheveled; ERK; extracellular signal-regulated kinase; F
Wnt pathway in Dupuytren disease: connecting profibrotic signals
Keywords: cDNA; complementary DNA; Fzd; Frizzled; HDF; human dermal fibroblasts; HPF; high power field; LRP; low-density lipoprotein receptor-related protein; siRNA; small interfering RNA; TGF; transforming growth factor; WISP1; Wnt1-inducible secreted protein 1;
Furazolidone induces apoptosis through activating reactive oxygen species-dependent mitochondrial signaling pathway and suppressing PI3K/Akt signaling pathway in HepG2 cells
Keywords: AML; acute myeloid leukemia; BSA; bovine serum albumin; DCFH-DA; 2â²,7â²-dichlorofluorescensin diacetate; DCM; dilated cardiomyopathy; DMSO; dimethyl sulfoxide; FBS; fetal bovine serum; FZD; furazolidone; HepG2; hepatoblastoma cell line; IGF-1; insulin-
Novel homozygous mutations in the WNT10B gene underlying autosomal recessive split hand/foot malformation in three consanguineous families
Keywords: WNT10B; wingless-type MMTV integration site family, member 10B; SHFM; Split hand foot malformation; TP63; tumor protein p63; DLX5; distal-less homeobox 5; bp; base pair; EDTA; Ethylene diamine tetra acetic acid; PCR; Polymerase Chain Reaction; cDNA; compl
Assessment of Frizzled 6 membrane mobility by FRAP supports G protein coupling and reveals WNT-Frizzled selectivity
Keywords: 7TM; seven transmembrane spanning; A1R; adenosine A1 receptor; DVL; disheveled; FRAP; fluorescence recovery after photobleaching; FZD; Frizzled; GFP; green fluorescent protein; GPCR; G protein-coupled receptor; NECA; 5â²-N-ethylcarboxamidoadenosine; NEM;
Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells
Keywords: 4E-BP1; eukaryotic initiation factor 4E binding protein 1; AMPK; 5â²-AMP-activated protein kinase; APC; adenomatous polyposis coli; CK1; casein kinase 1; CM; conditioned medium; eIF4E; eukaryotic initiation factor 4E; GSK3β; glycogen synthase kinase-3β
β-Catenin-dependent pathway activation by both promiscuous “canonical” WNT3a-, and specific “noncanonical” WNT4- and WNT5a-FZD receptor combinations with strong differences in LRP5 and LRP6 dependency
Keywords: WNT; FZD; LRP5/6; WNT/β-catenin signalling;
Wnt/β-catenin signaling regulates follicular development by modulating the expression of Foxo3a signaling components
Keywords: APC; adenomatosis polyposis coli; CTNNB1; β-catenin; DMSO; dimethylsulfoxide; CYP11A1; P450 cholesterol side chain cleavage; CYP19A1; cytochrome P450 aromatase; FBS; fetal bovine serum; Foxo; Forkhead box O; FZD; frizzled; GSK3β; glycogen synthase kinas
Is Alzheimer's disease related to metabolic syndrome? A Wnt signaling conundrum
Keywords: AMPK; AMP-activated protein kinase; STAT; activator of transcription; AGE; advanced glycation end products; AD; Alzheimer's disease; APP; amyloid precursor protein; Aβ; amyloid-β peptide; ACE; angiotensin converting enzyme; Ang I; angiotensin I; AR-II;
Transglutaminase 2 as a novel activator of LRP6/β-catenin signaling
Keywords: Fzd; Frizzled; LRP5/6; LRP5 or LRP6; APC; Adenomatosis Polyposis Coli; GSK3; Glycogen Synthase Kinase 3; TG2; Tissue transglutaminase; VSMCs; Vascular smooth muscle cells; TGases; Transglutaminases; ECM; Extracellular matrix; MEFs; Mouse embryonic fibrobl
Dynamic expression of secreted Frizzled-related protein 3 (sFRP3) in the developing mouse spinal cord and dorsal root ganglia
Keywords: CRD; cysteine-rich domain; CNS; central nervous system; dI; dorsal interneuron; dp1-6; dorsal progenitor domains 1-6; DRG; dorsal root ganglia; E9.5-18.5; Embryo day 9.5-18.5; FZD; Frizzled family of Wnt receptor; ISH; in situ hybridization; P0-
ReviewWnt signaling and hepatocarcinogenesis: Molecular targets for the development of innovative anticancer drugs
Keywords: HCC; hepatocellular carcinoma; FZD; frizzled; CSC; cancer stem cells; PCP; planar cell polarity; TCF/LEF; T-cell factor/lymphoid enhancer factor; TLE-1; transducin like enhancer-1; APC; adenomatous polyposis coli protein; GSK3β; glycogen synthase kinase
Modulation of the Wnt/beta-catenin pathway in human oligodendroglioma cells by Sox17 regulates proliferation and differentiation
Keywords: HOG; human oligodendroglioma; ODGs; oligodendrogliomas; OPCs; oligodendrocyte progenitor cells; Shh; sonic hedgehog; SFRP1; secreted frizzled related protein; Sox17; SRY-Box containing gene 17; CNPase; 2â²,3â²-cyclic-nucleotide 3â²-phosphodiesterase; M
Midbrain dopaminergic neurons: A review of the molecular circuitry that regulates their development
Keywords: A/P; anterior-posterior; BDNF; brain-derived neurotrophic factor; DA; dopaminergic/dopamine; DAT; dopamine transporter; D/V; dorso-ventral; E; embryonic day; En1/2; Engrailed-1/2; FGF8; fibroblast growth factor 8; Fzd; frizzled; GDNF; glial cell line-de
Distinctive microRNA signature associated of neoplasms with the Wnt/β-catenin signaling pathway
Keywords: FZD; Frizzled; LRP; LDL receptor-related protein; Dvl; Disheveled; APC; Adenomatous polyposis coli; CK1α; Casein kinase 1α; GSK3β; Glycogen synthase kinase 3β; HCC; Hepatocellular carcinoma; EZH2; Zeste homologue 2; sFRPs; Secreted frizzled-related
Frizzled7 as an emerging target for cancer therapy
Keywords: ALL; Acute lymphoblastic leukemia; APC; Adenomatous polyposis coli; CamKII; Calmodulin kinase II; Cthrc1; Collagen triple helix repeat containing protein; CK1; Caseine kinase 1; CTNNB1; β-catenin gene; CRD; Cysteine rich domain; CSC; Cancer stem cells; D
Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanism
Keywords: MSC; mesenchymal stem cell; PPARγ; peroxisome proliferator-activated receptor-γ; FABP4; fatty acid-binding protein 4; C/EBPα; CCAAT/enhancer-binding protein-α; WAT; white adipose tissue; BAT; brown adipose tissue; Id2; inhibitor of DNA binding 2; TLE3
WNT-5A stimulates the GDP/GTP exchange at pertussis toxin-sensitive heterotrimeric G proteins
Keywords: FZD; Frizzled; GPCR; G protein-coupled receptor; [γS]GTP; Guanosine 5â²-[γ-thio]triphosphate; SDS-PAGE; sodiumdodecylsulfate-polyacrylamide gelelectrophoresis; RT-PCR; reverse transcriptase polymerase chain reaction; QPCR; quantitative PCR; Frizzled; G
Identification of T-cell factor-4 isoforms that contribute to the malignant phenotype of hepatocellular carcinoma cells
Keywords: CtBP; C-terminal binding protein; FZD; Frizzled receptor; HCC; hepatocellular carcinoma; HMG; high mobility group; LEF; lymphoid enhancer factor; RT; reverse transcription; TCF; T-cell factor; TCF-4 isoform; HCC; Wnt;
Associate Editor: V.J. WattsRegulation of stem cell pluripotency and differentiation by G protein coupled receptors
Keywords: G protein coupled receptor; GPCR; Pluripotency; Stem cell; Differentiation; EB; Embryoid body; ES cells; Embyronic stem cells; FZD; Frizzled; GPCRs; G protein coupled receptors; GSK3; Glycogen synthase kinase 3; hATSCs; Human adipose tissue-derived mesenc
Altered growth factor signaling pathways as the basis of aberrant stem cell maturation in schizophrenia
Keywords: ACPT; acid phosphatase, testicular; APC; adenomatous polyposis coli; BCL; B-cell lymphoblastic leukemia; BDNF; brain-derived neurotrophic factor; BMP; bone morphogenic protein; CA; Cornus Ammonis; CDK; cyclin-dependent kinase; CK; casein kinase; CNV; copy
Protein kinase C is a target for diverse developmental neurotoxicants: Transcriptional responses to chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells
Keywords: ANOVA; analysis of variance; fgf; fibroblast growth factor gene family; fzd; frizzled gene family; NGF; nerve growth factor; PKA; protein kinase A; PKC; protein kinase C; wnt; wingless gene family; Organophosphate pesticide; Organochlorine pesticide; Meta
Expression of Wnt receptors in adult spiral ganglion neurons: frizzled 9 localization at growth cones of regenerating neurites
Keywords: cell surface receptors; cochlea; in situ hybridization; mice; microarray analysis; EfnB1; ephrin B1; Ephb; Eph receptor B; Fzd; frizzled homolog (Drosophila); GEO; gene expression omnibus; RT-PCR; reverse transcription and polymerase chain reaction; Ryk;
3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19)
Keywords: Wnt; Fzd; OPT; Mouse embryo; 3D expression patterns; Comparative analysis;
Distinct but redundant expression of the Frizzled Wnt receptor genes at signaling centers of the developing mouse brain
Keywords: Fzd; mid-/hindbrain boundary; isthmic organizer; cortical hemAcc., accession; A/P, anterior–posterior; bp, base pairs; CRD, cysteine-rich domain; D/V, dorsal–ventral; E, embryonic day; Fgf, fibroblast growth factor; Fzd, Frizzled (receptor); hFZD, human F