کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
218327 463192 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anodic voltammetric behavior of hydroxyurea and its electroanalytical determination in pharmaceutical dosage form and urine
ترجمه فارسی عنوان
رفتار ولتاژ آنودیک هیدروکسی اوره و تعیین الکتروآنالیز آن در فرم دوز دارو و ادرار
کلمات کلیدی
هیدروکسی اوره، ولتاژ سنجی، الکترود گرافیت مداد، الکتروآنالیز، اکسیداسیون
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
چکیده انگلیسی


• The electroanalysis of hydroxyurea (HU) at PGE was studied.
• The processes were irreversible and diffusion-controlled.
• The low detection limit with good selectivity and sensitivity was obtained.
• The method was applied for HU determination in real samples.
• A suitable mechanism was proposed.

A simple and a novel electroanalysis of hydroxyurea (HU) drug at pencil graphite electrode (PGE) has been investigated by using cyclic, linear sweep and differential pulse voltammetric techniques. The oxidation of HU was irreversible and exhibits a diffusion controlled process and is of pH dependence. The oxidation mechanism was proposed. The dependence of the current on pH, the concentration, nature of buffer, and scan rate was investigated to optimize the experimental conditions for the determination of HU. It was found that the optimum buffer for the determination of HU was pH of 8.0. In the range of 0.01 to 1.0 mM, the current measured by differential pulse voltammetry presents a good linear property as a function of the concentration of HU with a limit of detection of 7.89 μM. The developed method was successfully applied to HU determination in pharmaceutical formulation and human urine.

Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Electroanalytical Chemistry - Volume 755, 15 October 2015, Pages 109–114
نویسندگان
, , ,