کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
218599 | 463208 | 2014 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: None-catalyst and clean synthesis of symmetric and asymmetric indoles from electrochemical oxidation of 4-aminophenol and p-phenylenediamine in the presence of malononitrile in green media None-catalyst and clean synthesis of symmetric and asymmetric indoles from electrochemical oxidation of 4-aminophenol and p-phenylenediamine in the presence of malononitrile in green media](/preview/png/218599.png)
• Progress in green media.
• Electro-synthesis of new indoles.
• Synthesis of indoles without any catalyst and hard condition.
• Use of potential instead chemical reagents.
The mechanism of electrochemical oxidation of p-phenylenediamine and 4-aminophenol in the presence of malononitrile, as a nucleophile is studied in a phosphate buffer solution (0.15 M) mixed with ethanol (v:v) using the cyclic voltammetry, controlled-potential coulometry and UV-spectroscopy methods. The results obtained indicate that the oxidation form of p-phenylenediamine and 4-aminophenol participate in the 1,4-michael addition reactions with malononitrile via the ECECCC mechanism (E: electrochemical and C: chemical) for the electrochemical synthesis of new indole derivatives with good yield under controlled potential conditions. The products obtained were characterized after purification by the FT-IR, 1H NMR, 13C NMR, mass spectroscopy and elemental analysis.
The electro-oxidation of 4-aminophenol and p-phenylenediamine has been studied in the presence of malononitrile as a nucleophile. The results obtained confirm the synthesis of new indoles via the electro-organic synthesis.Figure optionsDownload as PowerPoint slide
Journal: Journal of Electroanalytical Chemistry - Volume 733, 1 November 2014, Pages 47–52