کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2191422 | 1097861 | 2009 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Physiologic and cardiac roles of β-arrestins Physiologic and cardiac roles of β-arrestins](/preview/png/2191422.png)
β-arrestin1 and β-arrestin2 were initially identified by sequence homology to visual arrestins and by their ability to bind to and inactivate signaling of the beta-2-adrenergic receptor in a process known as desensitization. While the role of β-arrestins in desensitization has been known for some time, more recent evidence has revealed that β-arrestins are multifunctional scaffolding proteins that are involved in numerous aspects of G protein-coupled receptor (GPCR) signaling. Interestingly, exciting new data shows that β-arrestins can mediate signaling in their own right independent of classical second messenger mediated signaling, and that this β-arrestin-mediated signaling may be cardioprotective. Identifying novel ligands for GPCRs that can block G protein-mediated signaling while simultaneously promoting β-arrestin-mediated signaling could provide powerful new therapies for cardiac disease.
Journal: Journal of Molecular and Cellular Cardiology - Volume 46, Issue 3, March 2009, Pages 300–308