کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
21918 43243 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prediction of Key Factor Controlling G1/S Phase in the Mammalian Cell Cycle Using System Analysis
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Prediction of Key Factor Controlling G1/S Phase in the Mammalian Cell Cycle Using System Analysis
چکیده انگلیسی

Control of the G1/S phase transition of the cell cycle contributes to the maintenance of homeostasis. It is well known that the disruption of the cell cycle is related to cell transformation and carcinogenesis. The G1/S phase transition involves a network of components that includes cyclins, cyclin-dependent kinases, and other proteins. Numerical simulation techniques and system analysis are expected to become powerful tools for investigating complex biological networks. To reach this goal, we designed a mathematical model of the G1/S phase transition. Using our model, we conducted a numerical simulation and comprehensive system analyses of this phase of the cell cycle. In this way, we were able to predict the key factors involved in the control of the G1/S transition.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Bioscience and Bioengineering - Volume 106, Issue 4, October 2008, Pages 368–374
نویسندگان
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