کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2194930 1550594 2011 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Heartbeat regulates cardiogenesis by suppressing retinoic acid signaling via expression of miR-143
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Heartbeat regulates cardiogenesis by suppressing retinoic acid signaling via expression of miR-143
چکیده انگلیسی

Cardiogenesis proceeds with concomitant changes in hemodynamics to accommodate the circulatory demands of developing organs and tissues. In adults, circulatory adaptation is critical for the homeostatic regulation of blood circulation. In these hemodynamics-dependent processes of morphogenesis and adaptation, a mechanotransduction pathway, which converts mechanical stimuli into biological outputs, plays an essential role, although its molecular nature is largely unknown. Here, we report that expression of zebrafish miR-143 is dependent on heartbeat. Knocking-down miR-143 results in de-repression of retinoic acid signaling, and produces abnormalities in the outflow tracts and ventricles. Our data uncover a novel epigenetic link between heartbeat and cardiac development, with miR-143 as an essential component of the mechanotransduction cascade.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mechanisms of Development - Volume 128, Issues 1–2, January–February 2011, Pages 18–28
نویسندگان
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