کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
219534 463278 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Voltammetric and spectroscopic studies on the interaction of tilmicosin with bovine serum albumin at different pHs
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Voltammetric and spectroscopic studies on the interaction of tilmicosin with bovine serum albumin at different pHs
چکیده انگلیسی

In this study, the voltammetric behavior of the interaction between tilmicosin (TIM) and bovine serum albumin (BSA) was investigated using voltammetry and UV–Vis spectroscopy techniques. In the presence of BSA, the main reductive signal of TIM gradually decreased without the appearance of new peaks. The formation of a 1:1 complex between TIM and BSA were determined at different pHs (3, 7.4 and 11). This interaction was also supported by ultraviolet spectroscopy. After the addition of TIM into the BSA solution, at pH 3 and 7.4, the absorption band of BSA at 217 nm decreased, shifted to smaller wavelengths, and narrowed. However, at pH 11, the absorbance of BSA at 217 nm decreased without the shift of maximum absorption wavelength. The interaction between TIM and BSA was mainly sourced from electrostatic or hydrophobic (intercalation) interactions.

The effects of bovine serum albumin (BSA) additions on the peak current and potential of tilmicosin (TIM) at different pHs revealed the presence of interaction between TIM and BSA.Figure optionsDownload as PowerPoint slideHighlights
► This study examines the interaction of bovine serum albumin (BSA) with tilmicosin (TIM).
► This interaction is mainly sourced from electrostatic or hydrophobic forces.
► The results will be useful for potential future applications in electrochemical sensors.
► Also, this work will play an important role in the drug–protein interactions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Electroanalytical Chemistry - Volume 657, Issues 1–2, 1 July 2011, Pages 128–134
نویسندگان
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