کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2199362 | 1099443 | 2006 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Dendrite-selective redistribution of the chemokine receptor CXCR4 following agonist stimulation Dendrite-selective redistribution of the chemokine receptor CXCR4 following agonist stimulation](/preview/png/2199362.png)
The chemokine SDF-1 is a secreted protein that plays a critical role in several aspects of neuron development through interaction with its unique receptor CXCR4. A key mechanism that controls neuron responsiveness to extracellular signals during neuronal growth is receptor endocytosis. Since we previously reported that SDF-1 regulates axon development without affecting the other neurites, we asked whether this could correlate with a compartment-selective trafficking of CXCR4. We thus studied CXCR4 behavior upon SDF-1 exposure in rat hippocampus slices and in transfected neuron cultures. A massive agonist-induced redistribution of CXCR4 in endosomes was observed in dendrites whereas no modification was evidenced in axons. Our data suggest that CXCR4 trafficking may play a role in mediating selective effects of SDF-1 on distinct neuronal membrane subdomains.
Journal: Molecular and Cellular Neuroscience - Volume 33, Issue 2, 9 October 2006, Pages 160–169