کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2199380 | 1099445 | 2006 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The final fates of neurogenin2-expressing cells include all major neuron types in the mouse retina The final fates of neurogenin2-expressing cells include all major neuron types in the mouse retina](/preview/png/2199380.png)
The molecular mechanism underlying vertebrate retinal development is not well understood. To examine whether neurogenin2 (ngn2) expression determines cell fate in the retina, we mapped the final fates of cells that once expressed ngn2, using the conditional, binary CreER™-LacZ system. We found LacZ+ cells in all 3 nuclear layers of the mouse retina and including all major types of neurons: photoreceptors, horizontal, bipolar, amacrine, and ganglion cells. The distribution of LacZ+ cells among the 3 nuclear layers closely resembled a theoretical distribution of total retinal cells. The temporal window in which each cell type was marked appeared nonrandom, and was similar to its birthdate and birth sequence. These data indicate that cells expressing ngn2 at some point in their life histories may later differentiate into a variety of cell types.
Journal: Molecular and Cellular Neuroscience - Volume 31, Issue 3, March 2006, Pages 463–469