کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2200274 1551278 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Arctigenin reduces neuronal responses in the somatosensory cortex via the inhibition of non-NMDA glutamate receptors
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Arctigenin reduces neuronal responses in the somatosensory cortex via the inhibition of non-NMDA glutamate receptors
چکیده انگلیسی


• Biologically active compounds, like arctigenin, a lignan produced by different plants may have neuroprotective effects.
• Arctigenin effectively reduces normal, physiological electrical responses both in brain slices and in whole brain.
• Arctigenin can cross the blood-brain barrier and it may exerts effect on nervous system of living animals.
• Arctigenin effectively binds to GluK1 subunit of kainate receptors.
• Different AMPA/KAIN types of ionotropic glutamate receptors may possess arctigenin binding properties.

Lignans are biologically active phenolic compounds related to lignin, produced in different plants. Arctigenin, a dibenzylbutyrolactone-type lignan, has been used as a neuroprotective agent for the treatment of encephalitis. Previous studies of cultured rat cerebral cortical neurones raised the possibility that arctigenin inhibits kainate-induced excitotoxicity. The aims of the present study were: 1) to analyse the effect of arctigenin on normal synaptic activity in ex vivo brain slices, 2) to determine its receptor binding properties and test the effect of arctigenin on AMPA/kainate receptor activation and 3) to establish its effects on neuronal activity in vivo. Arctigenin inhibited glutamatergic transmission and reduced the evoked field responses. The inhibitory effect of arctigenin on the evoked field responses proved to be substantially dose dependent. Our results indicate that arctigenin exerts its effects under physiological conditions and not only on hyper-excited neurons. Furthermore, arctigenin can cross the blood–brain barrier and in the brain it interacts with kainate sensitive ionotropic glutamate receptors. These results indicate that arctigenin is a potentially useful new pharmacological tool for the inhibition of glutamate-evoked responses in the central nervous system in vivo.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurochemistry International - Volume 97, July 2016, Pages 83–90
نویسندگان
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