کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2201882 1100046 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Kinetic versus allosteric mechanisms to explain insurmountable antagonism and delayed ligand dissociation
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Kinetic versus allosteric mechanisms to explain insurmountable antagonism and delayed ligand dissociation
چکیده انگلیسی

The present review addresses the theories which have been advanced to explain experimental observations dealing with insurmountable antagonism and accelerated radioligand dissociation in the presence of an excess unlabelled ligand. We came to the perception that, for each of these phenomena, the theories can be placed into two distinctive categories. The “kinetic” interpretations attribute these phenomena to, respectively, the ability of antagonists to form long-lasting complexes with their cognate receptor and the ability of dissociated ligands to bind again to the same or neighbouring receptors rather than to diffuse away from the cell surface. On the other hand, these observations can also be explained by negative allosteric interactions among topographically distinct ligand binding sites at the same receptor or di/multimeric receptor complex.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurochemistry International - Volume 51, Issue 5, October 2007, Pages 254–260
نویسندگان
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