کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2202877 1100401 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
New insights in endosomal dynamics and AMPA receptor trafficking
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
New insights in endosomal dynamics and AMPA receptor trafficking
چکیده انگلیسی

The trafficking mechanisms that control the density of synaptic AMPA-type glutamate receptors have received significant attention because of their importance for regulating excitatory synaptic transmission and synaptic plasticity in the hippocampus. AMPA receptors are synthesized in the neuronal cell body and reach their postsynaptic targets after a complex journey involving multiple transport steps along different cytoskeleton structures and through various stages of the endocytic pathway. Dendritic spines are important sites for AMPA receptor trafficking and contain the basic components of endosomal recycling. On induction of synaptic plasticity, internalized AMPA receptors undergo endosomal sorting and cycle through early endosomes and recycling endosomes back to the plasma membrane (model for long-term potentiation) or target for degradation to the lysosomes (model for long-term depression). Exciting new studies now provide insight in actin-mediated processes that controls endosomal tubule formation and receptor sorting. This review describes the path of AMPA receptor internalization up to sites of recycling and summarizes recent studies on actin-mediated endosomal receptor sorting.


► Linking AMPA receptor endocytosis to actin-mediated endosomal receptor sorting.
► Endocytic internalization of AMPA receptors in neurons.
► AMPA receptor sorting and recycling in neurons.
► Role of actin cytoskeleton in receptor endocytosis in non-neuronal cells.
► Role of actin microdomains in endosomal recycling routes in non-neuronal cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 22, Issue 5, July 2011, Pages 499–505
نویسندگان
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