کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2202893 | 1100402 | 2011 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Control of polarized cell morphology and motility by adherens junctions Control of polarized cell morphology and motility by adherens junctions](/preview/png/2202893.png)
Cell–cell interactions play a key role in tissue homeostasis. Intercellular adhesions share the complex task of establishing and maintaining tissue architecture while allowing tissue growth, renewal and repair. In particular, adherens junctions (AJs) have been implicated in the formation of diverse tissues and organs like epitheliums, blood vessels or the central nervous system. At the cellular level, AJs are well known for their essential role in epithelial cell differentiation and baso-apical polarity. They also contribute to the control of cell polarity to promote neuronal morphogenesis, growth cone guidance and directed migration in a variety of cell types during embryonic development. AJs based on classical cadherin- and nectin-mediated cell–cell interactions control local membrane dynamics to polarize cell morphology and motility at the single cell level and to coordinate cell shape changes and motile behaviour at the tissue level. I review here the molecular mechanisms allowing control of polarized cell morphology and motility by AJs.
► Cadherins and nectins transmit information that influences cell polarity.
► AJs-mediated signalling locally influences cytoskeleton organization and membrane dynamics.
► AJs direct neuron and epithelial polarized growth.
► Cadherins support polarized cell motility.
Journal: Seminars in Cell & Developmental Biology - Volume 22, Issue 8, October 2011, Pages 850–857