کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2204487 1100788 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Making connections: interorganelle contacts orchestrate mitochondrial behavior
ترجمه فارسی عنوان
برقراری ارتباط: ارتباطات بین مولکولی رفتارهای میتوکندری را مرتب می کند
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی


• ER contacts control mitochondrial fission, distribution, and autophagy.
• Plasma membrane contacts coordinate mitochondrial partitioning in yeast.
• Peroxisome contacts contribute to mitochondrial behavior.

Mitochondria are highly dynamic organelles. During their life cycle they frequently fuse and divide, and damaged mitochondria are removed by autophagic degradation. These processes serve to maintain mitochondrial function and ensure optimal energy supply for the cell. It has recently become clear that this complex mitochondrial behavior is governed to a large extent by interactions with other organelles. In this review, we describe mitochondrial contacts with the endoplasmic reticulum (ER), plasma membrane, and peroxisomes. In particular, we highlight how mitochondrial fission, distribution, inheritance, and turnover are orchestrated by interorganellar contacts in yeast and metazoa. These interactions are pivotal for the integration of the dynamic mitochondrial network into the architecture of eukaryotic cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 24, Issue 9, September 2014, Pages 537–545
نویسندگان
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