کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
220714 463347 2008 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Theory of polymer entrapped enzyme ultramicroelectrodes: Fundamentals
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Theory of polymer entrapped enzyme ultramicroelectrodes: Fundamentals
چکیده انگلیسی

We have developed a theoretical description of the amperometric response of ultramicroelectrode (UME) biosensors formed via enzyme entrapment. Our model allows for multiple enzymes and co-substrates, and results in a closed-form analytical expression for the steady-state current response of the disk ultramicroelectrode. It captures the effects of enzyme-entrapment domain size, species transport properties (which can be different in the polymer and surrounding electrolyte), enzyme kinetics, and axisymmetric diffusion. Assumptions inherent in the derivation are carefully explained, as are the resulting limits on the applicability of the results. The ability to theoretically predict the response of enzyme entrapped UMEs should enable improved design, operation, and data interpretation for this important class of biosensors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Electroanalytical Chemistry - Volume 612, Issue 2, 15 January 2008, Pages 208–218
نویسندگان
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