Inhibitory effect of d-allose on neutrophil activation after rat renal ischemia/reperfusion

d-Allose is one of the rare sugars produced from d-psicose. We examined whether d-allose reduces the extent of rat renal ischemia/reperfusion (I/R) injury by suppressing the activation of neutrophils. The renal concentrations of cytokine-induced neutrophil chemoattractant (CINC)-1 and myeloperoxidase were significantly increased after renal I/R. These increases were significantly inhibited by d-allose administration. Furthermore, d-allose significantly inhibited the increase in the concentrations of blood urea nitrogen (BUN), creatinine, N-acetyl β-d-glucosaminidase (NAG) and histopathologic changes after renal I/R. These findings strongly suggest that d-allose protects against I/R-induced renal injury by inhibiting the activation of neutrophils that play an important role in I/R-induced renal injury. These findings may have important implications in understanding the biologic functions of d-allose. d-Allose may prove useful in renal surgery and transplantation.