کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
230997 | 1427406 | 2012 | 7 صفحه PDF | دانلود رایگان |
This paper reports on the melting point depression and polymorphic transformations of Piroxicam in supercritical carbon dioxide and in mixtures with ethanol, acetone or ethyl acetate as co-solvents. It further reports on the formation of the inclusion complexes of Piroxicam which is liquefied in these fluid mixtures with β-cyclodextrin. It is shown that in carbon dioxide the melting temperature of Piroxicam is reduced by 17 °C, from 200 °C to 183 °C. The melting temperature was further depressed in mixtures containing a small amount of a co-solvent. The largest melting point depression was 37 °C and was observed in the fluid mixture containing 10 wt% ethanol. Piroxicam that was melted and recrystallized in carbon dioxide or carbon dioxide + co-solvent mixtures displayed distinct differences in its infrared spectra, thermal behavior and X-ray diffraction patterns as compared to its unprocessed form. Melting in CO2 and CO2 + co-solvent mixtures was found to lead to a polymorphic transformation of Piroxicam from the β crystal form (cubic) to the α crystal form (needle). It was further found that melting of Piroxicam in 90:10 wt% CO2:ethanol fluid mixture promotes inclusion complex formation with β-cyclodextrin leading to a 1:1 molar ratio complex. Inclusion complex formation via melting in supercritical fluid mixtures is now being proposed as a new processing methodology.
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► The melting point of Piroxicam was depressed in carbon dioxide and its mixtures with ethanol, acetone or ethyl acetate.
► Piroxicam underwent a polymorphic transformation when recrystallized from the molten state in these fluids.
► Complex formation with β-cyclodextrin is promoted with Piroxicam in the molten state in CO2 + ethanol fluid mixtures.
► A new process is described for forming inclusion complexes by melting of the drug in supercritical fluid mixtures.
Journal: The Journal of Supercritical Fluids - Volume 71, November 2012, Pages 19–25