Effect of menthol as solid cosolvent on the solubility enhancement of clozapine and lamorigine in supercritical CO2

The solubilities of mixed clozapine and menthol also lamotrigine and menthol in supercritical carbon dioxide were determined at 313 and 323 K and over pressure ranging from 123 to 337 bar. The solubility of both solutes with solid cosolvent system is observed to increase relative to the value of the corresponding without solid cosolvent system. As compared with their respective binary system (without solid cosolvent), the mixed clozapine (with solid cosolvent) solubility enhancement greatly by around 56 times and the lamotrigine one does by approximately eight times. In presence of menthol these chemicals have solubilities with values ranging from 1.88 × 10−4 to 4.48 × 10−4 (clozapine) and 0.09 × 10−4 to 0.36 × 10−4 (lamotrigine) mole fraction. The solubility data were correlated using five semi-empirical density-based models (Chrastil, Bartle, K–J, M–T and Thakur models). Correlated results for clozapine with the Chrastil, M–T, K–J, and Bartle models and for lamotrigine with the Chrastil, M–T and Bartel models are in excellent agreement with the experimental data.

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