کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
231821 | 1427451 | 2008 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Preparation of inclusion complex of piroxicam with cyclodextrin by using supercritical carbon dioxide Preparation of inclusion complex of piroxicam with cyclodextrin by using supercritical carbon dioxide](/preview/png/231821.png)
Forming complexes with cyclodextrins can enhance the dissolution rate, the stability, the solubility and the bioavailability of a drug. In this work, piroxicam/β-cyclodextrin complexes were prepared at solid state by means of supercritical carbon dioxide. The influence of temperature, residence time, water content and a ternary agent, l-lysine, were studied. The complex was characterized by Differential Scanning Calorimetry, Scanning Electronic Microscope and dissolution profile in water. Finally, a complete inclusion was achieved for a piroxicam/β-cyclodextrin/l-lysine mixture by keeping a physical mixture of the three compounds (1:2:1.5 molar ratio) for 2 h in contact with CO2 at 150 °C and 15 MPa.
Piroxicam/β-cyclodextrin complexes were prepared at solid state by means of supercritical CO2. The influence of several operating parameters were studied and finally, a complete inclusion was achieved for a piroxicam/β-cyclodextrin/l-lysine mixture by keeping a physical mixture of the three compounds (1:2:1.5 molar ratio) for 2 h in contact with CO2 at 150 °C and 15 MPa.Figure optionsDownload as PowerPoint slide
Journal: The Journal of Supercritical Fluids - Volume 47, Issue 2, December 2008, Pages 326–332